[en] Objective: To introduce a new descending venography of deep vein in lower extremity via a percutaneous great saphenous access. The clinical value and practicability were also investigated. Methods: The proximal great saphenous vein was located by duplex ultrasound under fluoroscopy. Results: The percutaneous great saphenous access was successfully established on 28 limbs (87.5%) out of 32, puncture was failed on the other 4 limbs (12.5%). According to Kistner grading the venography revealed 2 limbs in grade I (7.1%), 17 limbs in grade II (60.7%), 6 limbs in grade III (21.4%), 3 limbs in grade IV (10.7%). A 1-8 months' follow-up is available for all patients. No complication was found except some local subcutaneous gore. Conclusion: The descending venography of lower extremity's deep vein via a percutaneous great saphenous access is a less-invasive method with higher success rate and few complications. This method can be used to substitute descending venography via the femoral access. (authors)