[en] The chemotherapy delivered before the chemo radiotherapy allows to identify the patients that can get a benefit of this concomitant radio chemotherapy. The oxiplatine concomitant weekly administration, of 5-fluoro-uracil in continuous perfusion, and radiotherapy is possible with an acceptable toxicity in the treatment of locally evolved non resectable pancreas carcinomas. The results in term of survival without progression and global survival seem interesting in comparison with a chemoradiotherapy based on 5-fluoro-uracil in continuous perfusion. (N.C.)