[en] N-succinimidyl-4-[¹⁸F]fluorobenzoate([¹⁸F]SFB) was prepared using a multifunction chemistry process control unit module. The dried K₂₂₂/¹⁸F^- was resolubilized with a solution of 4-trimethlammoniumbenzoate trifluoromethane-sulfonate and reacted to produce ethyl-4-[¹⁸F] fluorobenzoate. The ethylester was subsequently hydrolyzed using alkali to obtain the 4-[¹⁸F] fluorobenzoic acid([¹⁸F]FBA). After purifying through Sep-Pak C18 cartridge, [¹⁸F]FBA was dissolved with TSTU in CH₃CN and reacted to produce [¹⁸F]SFB. The nucleophilic reaction reated for 10 min at 115 degree C in the covered vial, mixturing solvents with netrogen for several seconds and the ethylester was subsequently hydrolyzed using alkali. The decay-corrected yields of [¹⁸F]SFB were much higher. The radiochemical yield of [¹⁸F]SFB is (28.2±1.9) (n=5), and radiochemical purity of [¹⁸F]SFB is more than 90%. The whole reaction time is only 45 min from ¹⁸F-F^- to [¹⁸F]SFB. The whole reaction time can be shorten and the yield of product is high by using the multifunction chemistry process control unit module. It is a quick and highly efficient method for labeling bioactive compound. (authors)