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Yoo, Byung Sun; Park, Sun Young; Jang, Eun Jung
Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)2005
Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)2005
AbstractAbstract
[en] To evaluate the radioprotective efficacy of candidate compounds, we examined the effects of selenium compounds, melatonin, and propolis on the colony forming efficiency (CFE) of gamma-irradiated CHO cells. - Protective effects of selenium compounds against radiation-induced cytotoxicity Sodium selenite showed protective effects at low concentrations against radiation-induced toxicity in CHO cells, whereas its effects were weak at higher concentrations. Selenomethionine also reduced the radiation-induced cytotoxicity. Both of these compounds showed highest protective effects at the concentration of 1 uM. - Protective effects of melatonin against radiation-induced cytotoxicity Melatonin showed the protective effects against radiation-induced cytotoxicity, and the protection was highest at 1 mM concentration. - Protective effects of selenium compounds against hydrogen peroxide-induced cytotoxicity Propolis showed dose-dependent inhibition of hydrogen peroxide-induced cytotoxicity. In particular, the highest inhibition was observed when propolis were treated at 0.3 and 1 ng/ml 24h prior to the hydrogen peroxide treatment. The protective effects of propolis was observed only when it was pretreated at least 8 hours before hydrogen peroxide treatment
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Mar 2005; 20 p; Also available from KAERI; 9 figs
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