[en] Two-photon exchange contributions have potentially broad ranging impact on several charged lepton scattering measurements. Previously believed to be extremely small, based in part on comparisons of positron scattering and electron scattering in the 1950s and 1960s, recent data suggest that the corrections may be larger than expected, in particular in kinematic regions that were inaccessible in these early positron scattering measurements. Additional measurements using positron beams at Jefferson Lab would allow for a detailed investigation of these contributions in a range of reactions and observables.