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[en] In this work the biodistribution of radioimmunoconjugate 90Y-DOTA-hR3 was modeled by using an artificial neural network. In vivo stability of 90Y-DOTA-hR3 was determined in healthy male Wistar rats at 4, 24 and 48 hours, in different organs. A model describing the relationship between, by one hand, the incorporated dose and, by the other hand, organ and time was developed by using a multilayer perceptron neural network. Adjusted model was analyzed by several statistical tests. Outcomes shown that proposed neural model describes the relationship between the studied variables in a proper way. (Author)
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Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear (CEADEN), La Habana (Cuba); Instituto Superior de Tecnologias y Ciencias Aplicadas (InSTEC), La Habana (Cuba); Agencia de Energia Nuclear y Tecnologias de Avanzada (AENTA), La Habana (Cuba); 1 CD-ROM; ISBN 978-959-7136-79-8; 
; Feb 2011; 266 KB; WONP-NURT 2011: 7. International Symposium on Nuclear and Related Techniques; La Habana (Cuba); 7-11 Feb 2011; 13. Workshop on Nuclear Physics; La Habana (Cuba); 7-11 Feb 2011; Available from Centro de Aplicaciones Tecnologica y Desarrollo Nuclear (CEADEN), La Habana (CU). Email. marta@ceaden.edu.cu; Centro de Gestion de la Informacion y Desarrollo de la Energia (Cubaenergia), La Habana (CU) ,Email. belkis@cubaenergia.cu; 9 refs.; 2 tabs.; 3 figs.
; Feb 2011; 266 KB; WONP-NURT 2011: 7. International Symposium on Nuclear and Related Techniques; La Habana (Cuba); 7-11 Feb 2011; 13. Workshop on Nuclear Physics; La Habana (Cuba); 7-11 Feb 2011; Available from Centro de Aplicaciones Tecnologica y Desarrollo Nuclear (CEADEN), La Habana (CU). Email. marta@ceaden.edu.cu; Centro de Gestion de la Informacion y Desarrollo de la Energia (Cubaenergia), La Habana (CU) ,Email. belkis@cubaenergia.cu; 9 refs.; 2 tabs.; 3 figs.