[en] U.S.-ITER is responsible for the design, engineering, and procurement of the Tokamak Cooling Water System (TCWS). TCWS is designed to provide cooling and baking for client systems that include the first wall/blanket, vacuum vessel, divertor, and neutral beam injector. Additional operations that support these primary functions include chemical control of water provided to client systems, draining and drying for maintenance, and leak detection/localization. TCWS interfaces with 27 systems including the secondary cooling system, which rejects this heat to the environment. TCWS transfers heat generated in the Tokamak during nominal pulsed operation - 850 MW at up to 150 C and 4.2 MPa water pressure. Impurities are diffused from in-vessel components and the vacuum vessel by water baking at 200-240 C at up to 4.4 MPa. TCWS is complex because it serves vital functions for four primary clients whose performance is critical to ITER's success and interfaces with more than 20 additional ITER systems. Conceptual design of this one-of-a-kind cooling system has been completed; however, several issues remain that must be resolved before moving to the next stage of the design process. The 2004 baseline design indicated cooling loops that have no fault tolerance for component failures. During plasma operation, each cooling loop relies on a single pump, a single pressurizer, and one heat exchanger. Consequently, failure of any of these would render TCWS inoperable, resulting in plasma shutdown. The application of reliability, availability, maintainability, and inspectability (RAMI) tools during the different stages of TCWS design is crucial for optimization purposes and for maintaining compliance with project requirements. RAMI analysis will indicate appropriate equipment redundancy that provides graceful degradation in the event of an equipment failure. This analysis helps demonstrate that using proven, commercially available equipment is better than using custom-designed equipment with no field experience and lowers specific costs while providing higher reliability. This paper presents a brief description of the TCWS conceptual design and the application of RAMI tools to optimize the design at different stages during the project.