[en] In photochemotherapy, ultraviolet radiation (UVR: 280-400 nm) or visible light is combined with a photosensitizing drug to produce a therapeutic effect. Importantly, the beneficial impact of photochemotherapy is not achieved by the drug or radiation alone. It is a proven therapeutic strategy for a number of non-malignant hyper proliferative skin conditions and various cancers. All existing photochemotherapies have drawbacks - for example the association of (psoralen plus UVA) PUVA with the development of skin cancer, and pain that is often associated with photodynamic therapy (PDT) treatment of skin lesions. In this study, we explored an alternate possibility to address this need by exploiting coralyne-mediated DNA photo-sensitisation to low and non-toxic doses of UVA radiation. Current investigation also illustrates an overview of the mechanism of action underlying coralyne mediated photosensitization of cancer cells. (author)