[en] A flexible fast spectrum research reactor MYRRHA able to operate in subcritical (driven by a proton accelerator) and critical modes is being developed in SCK-CEN. In the framework of IP EUROTRANS programme the XT-ADS model has been investigated for MYRRHA. This paper reports the comparison of the sensitivity coefficients calculated for different calculation models and the uncertainties deduced from various covariance data for the discussion on the reliability of XT-ADS neutronics design. Sensitivity analysis is based on the comparison of three-dimensional heterogeneous and two-dimensional RZ calculation models. Three covariance data sets were employed to perform uncertainty analysis. The obtained sensitivity coefficients differ substantially between the 3D heterogeneous and RZ homogenized calculation models. The uncertainties deduced from the covariance data strongly depend on the covariance data variation. The covariance data of the nuclear data libraries is an open issue to discuss the reliability of the neutronics design. The uncertainties deduced from the covariance data for XT-ADS are 0.94% and 1.9% by the SCALE-6 44-group and TENDL-2009 covariance data, accordingly. The uncertainties exceed the 0.3% Δk (confidence level 1σ) target accuracy level. To achieve this target accuracy, the uncertainties should be improved by experiments under adequate conditions such as LBE or Pb moderated environment with MOX or Uranium fuel