[en] We study the influence of quantum interference on 2D sub-half-wavelength atom localization in a four-level atom driven by three external fields with a loop structure. When the dipoles of the two transitions from two upper levels to the lower level are parallel to each other, quantum interference between the two transitions arises. The analytical expression of conditional position probability (CPP) distribution is obtained using the iterative method. We discuss the influence of the detuning of the spontaneously emitted photon, the Rabi frequency of the microwave field and the dipole moment matrix element alignment p on the CPP. 2D sub-half-wavelength atom localization is obtained and the spatial resolution is improved significantly compared with cases with no quantum interference. (letter)