[en] Objective: to assess the efficacy and safety of oral misoprostol for induction of labor. Study design: prospective interventional case series Place and duration: The study was conducted at Obstetrics and Gynaecology Department Ziauddin Hospital Kemari campus which is affiliated with Ziauddin University, from 1st January 2014 to 31st December 2015. Material and Method: Women with live singleton pregnancy of > 30 weeks gestation with cephalic presentation and bishop score <7 with an indication for induction of labor were recruited. Oral misoprostol 50 /meu/g was given orally at 6 hourly interval for 4 doses followed by 24 hour rest and repetition of 50/meu/g again at 6 hourly interval upto a maximum of 8 doses or till labor was induced. Feto-maternal outcome, mode of delivery and induction to delivery interval in hours was noted. Results: Th e mean induction to delivery interval was 23.36 hours. 133 patients (67 percent) delivered within 24 hours. 67 patients (33.5 percent) delivered at >24 hours. Overall vaginal delivery was achieved in 165(83.5 percent) patients. 163 (81.5 percent) had spontaneous vaginal delivery, 2(1 percent) had forceps and 2(1 percent) had vaccum vaginal delivery while 33(16.5 percent) patients had to undergo cesarean section. There was no case of uterine hyper stimulation or rupture. There was no intrauterine death attributable to induction. The only neonatal death was in a 32 week severely preeclamptic patient. Conclusion: Oral Misoprostol is safe and effective method of labor induction in third trimestor. (author)