[en] In this paper we present two configurations of innovative gamma detectors using Cherenkov light for time-of-flight—Positron Emission Tomography (PET). The first uses heavy crystals as a Cherenkov radiator to develop a demonstrator for a whole body PET scanner with high detection efficiency. We demonstrated a 30% detection efficiency and a 180 ps (FWHM) time resolution, mainly limited by the time transit spread of the photomultiplier. The second configuration uses an innovative liquid, the TriMethyl Bismuth, to develop a high precision brain-scanning PET device with time-of-flight capability. According to Geant4 simulation, we expect to reach a precision of 150 ps (FWHM) and an efficiency of about 25%.