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Rozenblum, Laura; Mokrane, Fatima-Zohra; Yeh, Randy; Sinigaglia, Mathieu; Besson, Florent; Seban, Romain-David; Chougnet, Cecile N; Revel-Mouroz, Paul; Zhao, Binsheng; Otal, Philippe; Schwartz, Lawrence H.; Dercle, Laurent, E-mail: ld2752@cumc.columbia.edu2019
AbstractAbstract
[en] Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms that secrete peptides and neuro-amines. pNETs can be sporadic or hereditary, syndromic or non-syndromic with different clinical presentations and prognoses. The role of medical imaging includes locating the tumor, assessing its extent, and evaluating the feasibility of curative surgery or cytoreduction. Pancreatic NETs have very distinctive phenotypes on CT, MRI, and PET. PET have been demonstrated to be very sensitive to detect either well-differentiated pNETs using 68Gallium somatostatin receptor (SSTR) radiotracers, or more aggressive undifferentiated pNETS using 18F-FDG. A comprehensive interpretation of multimodal imaging guides resectability and cytoreduction in pNETs. The imaging phenotype provides information on the differentiation and proliferation of pNETs, as well as the spatial and temporal heterogeneity of tumors with prognostic and therapeutic implications. This review provides a structured approach for standardized reading and reporting of medical imaging studies with a focus on PET and MR techniques. It explains which imaging approach should be used for different subtypes of pNET and what a radiologist should be looking for and reporting when interpreting these studies.
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Source
Copyright (c) 2019 Springer Science+Business Media, LLC, part of Springer Nature; Country of input: International Atomic Energy Agency (IAEA)
Record Type
Journal Article
Journal
Abdominal Radiology (Online); ISSN 2366-0058; ; v. 44(7); p. 2474-2493
Country of publication
BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM, DISEASES, ELEMENTS, EMISSION COMPUTED TOMOGRAPHY, ENDOCRINE GLANDS, FLUORINE ISOTOPES, GLANDS, HOURS LIVING RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPE APPLICATIONS, ISOTOPES, LIGHT NUCLEI, MEDICINE, METALS, NANOSECONDS LIVING RADIOISOTOPES, NUCLEAR MEDICINE, NUCLEI, ODD-ODD NUCLEI, ORGANIC COMPOUNDS, ORGANS, PROTEINS, RADIOISOTOPES, RADIOLOGY, TOMOGRAPHY
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