[en] The enthalpies of N-methylglycine dissolution in aqueous solutions of acetonitrile (AN), 1,4-dioxane (DO), acetone (AC), and dimethylsulfoxide (DMSO) at a mole fraction of an organic solvent x₂ of 0‒0.25 and T = 298.15 K. The results of the experiment were used to calculate the standard values of the enthalpies of dissolution (${\mathrm{\Delta <!--\; ??\; -->}}_{\text{sol}}{H}^{\circ <!--\; ???\; -->}$) and transfer (${\mathrm{\Delta <!--\; ??\; -->}}_{\text{tr}}{H}^{\circ <!--\; ???\; -->}$) of N-methylglycine from water to the mixed solvent, as well as the enthalpy coefficients of pairwise interactions (h_xy) of N-methylglycine with organic solvent molecules. The influence of the composition of an aqueous–organic mixture and the structure of organic solvents on the enthalpy characteristics of dissolution and transfer of N-methylglycine is considered. The effect of energetics of intermolecular interactions between the components of a mixed solvent on intermolecular interactions of N-methylglycine with co-solvent molecules is estimated. The main properties of the cosolvent that significantly affect the energetics of interaction with N-methylglycine molecules in an aqueous solution are determined—polarity/polarizability and the electron-donating ability of the cosolvent.