[en] Ordering and self-organization are critical in determining the dynamics of reaction-diffusion systems. Here we show a unique pattern formation mechanism, dictated by the coupling of thermodynamic instability and kinetic anisotropy. Intrinsically different from the physical origin of Turing instability and patterning, the ordered patterns we obtained are caused by the interplay of the instability from uphill diffusion, the symmetry breaking from anisotropic diffusion, and the reactions. To understand the formation of the void/gas bubble superlattices in crystals under irradiation, we establish a general theoretical framework to predict the symmetry selection of superlattice structures associated with anisotropic diffusion. Through analytical study and phase field simulations, we found that the symmetry of a superlattice is determined by the coupling of diffusion anisotropy and the reaction rate, which indicates a new type of bifurcation phenomenon. Our discovery suggests a means for designing target experiments to tailor different microstructural patterns.