[en] Objective: To study the effect of fluvastatin on changes of serum Hcy, IL-6 and IL-8 levels in patients with coronary heart disease. Methods: 88 patients with CHD were random in divided into fluvastatin-treated group(35 cases) and conventional therapy group (53 cases). In addition, 50 healthy persons served as control group. Serum IL-6, IL-8(with RIA) and Hcy (with ELISA) levels were measured both before and after treatment for 2 months with fluvastatin in these CHD patients as well as in controls. Results: (1) Before treatment, the levels of serum Hcy, IL-6, IL-8 were remarkably higher in the patients with CHD than those in controls (P < 0.01). (2) After treatment, the levels of serum Hcy, IL-6, IL-8 in patients with fluvastatin-treated group decreased significantly (P < 0.01), but the levels were not much changed in the conventional therapy group. Conclusion: Fluvastatin have anti-infammatory and therapeutic effect on the patients with CHD. (authors)