[en] We show that fully aligned neutron-proton pairs play a crucial role in the low-energy spectroscopy of nuclei with valence nucleons in a high-j orbital. Their dominance is valid in nuclei with valence neutrons and protons in different high-j orbitals as well as in N = Z nuclei, where all nucleons occupy the same orbital. We demonstrate analytically this generic feature of the neutron-proton interaction for a variety of systems with four valence nucleons interacting through realistic, effective forces. The dominance of fully aligned neutron-proton pairs results from the combined effect of (i) angular momentum coupling and (ii) basic properties of the neutron-proton interaction. (authors)