[en] PIPESTRESS is professional software for mechanical calculation and analysis. Containing standard such as ASME, RCC-M, EN, it can be used in nuclear grade or non-nuclear grade design and check analysis with modeling, calculating and post-analysis module. As used widely in Westinghouse, AREVA and EDF companies, PIPESTRESS can be applied to three-dimensional calculation of structure, supported facility for heat or fatigue analysis. With application of PIPESTRESS software, the nuclear piping system in the nuclear power plant was used as an analysis model to calculate the weight, thermal expansion, seismic and so on. The selection of ASME design standard was used for static evaluation, through the calculation, the stress and the maximum stress ratios under the condition of different stress combinations were gotten. The results were shown that, some parts of the system could meet the ASME standard limit requirements. Stress analysis and evaluation by the application of PIPESTRESS software, which can not only ensure the safety of the pipeline system, and also can optimize the design. The software was played an important role in the construction and operation of a nuclear power plant. (authors)