[en] Highlights: • The CHA used in the current study show poor biocompatibility. • The biocompatibility of CHA is improved by either coating with a layer of OCP or by adding BMP-2. • CHA modified by OCP coating with BMP-2 show improved biocompatibility and osteoinductive. -- Abstract: (1) To determine whether the biocompatibility of coralline hydroxyapatite (CHA) granules could be improved by using an octacalcium phosphate (OCP) coating layer, and/or functionalized with bone morphogenetic protein 2 (BMP-2), and (2) to investigate if BMP-2 incorporated into this coating is able to enhance its osteoinductive efficiency, in comparison to its surface-adsorbed delivery mode.