[en] At present, in many preclinical and clinical studies, the mechanism of action, combination therapy, therapeutic efficacy, and side effects of vascular endothelial growth factor (VEGF) inhibitors in combination with radiotherapy and immunotherapy are being explored. Some studies have reported improved tumor control after the addition of anti-VEGF intervention to radiotherapy. Nevertheless, how to administer these three modalities to achieve optimal response with minimal toxicity remains to be investigated. In this article, the mechanism and research progress on anti-VEGF therapy, radiotherapy and immunotherapy were reviewed. (authors)