[en] The qualitative features of large scale structures in the simplest case of kinetic plasma turbulence, the electron beam-plasma instability, are described. A New approach is introduced, resting on a classical mechanics technique. It starts from a N-body description of the plasma, and leads to the derivation of a set of equations describing the self-consistent evolution of Langmuir waves and near-resonant particles. (authors)

[en] The complete understanding of evaporating systems still motivates important scientific activity for both fundamental and industrial applications. We propose here to investigate numerically the properties of water evaporating droplets on a heating substrate. Droplets are assumed to be pinned and axisymmetric for the duration of the evaporation process. The description of the evaporative dynamics is based on stationary hydrodynamic equations for the droplet whereas surrounding air properties are essentially determined by Laplace equation for the temperatures. Construction of the model is presented and the justification of stationary approximations discussed. The role of the temperature of the heating substrate and droplet radius are investigated. Influence of relative humidity is also discussed and indicates a strong influence only for low substrate temperatures. An empirical rule for droplet evaporation time as a function of the basic parameters of the system is finally proposed. Our main objective here is to propose guidelines for small sessile and pinned droplet experiments to help the understanding of the influence of three major parameters: temperature of the heating substrate, droplet size and far field humidity. (authors)

[en] Limestone-siliceous and siliceous concretes are used in reactor pits of French nuclear power plants. In case of severe nuclear reactor accident, failure of the reactor vessel would lead to interaction between molten corium (hot melt of nuclear fuel) and concrete. This paper focuses on the thermal degradation of both limestone-siliceous and siliceous concretes till 1000 degrees C. Thermo-Gravimetric Analysis (TGA) and Mercury Intrusion Porosimetry (MIP) are used to measure mass loss and porosity modification. As concretes are heterogeneous materials, sampling and representativeness have been addressed. TGA experiments show larger mass loss for limestone-siliceous concretes due to the decarbonation of calcium carbonate gravels when T > 800 degrees C. MIP experiments demonstrate a 100% increase of porosity for limestone-siliceous (resp. siliceous) concretes when T > 500 degrees C (resp. T > 800 degrees C). The consequences of these results are discussed in the frame of experimental tests on prototypical corium systems aimed at describing the key-phenomena involved in molten corium concrete interaction. (authors)

[en] Although nonlinear relaxation transients are very common in nature, very few studies are devoted to its characterization, mainly due to its short time duration. In this paper, we present a study about the nature of relaxation transients in a kicked damped oscillator, in which transients are generated in terms of continuous fast changes in the parameters of the system. We have found that transient dynamics can be described, rather than in terms of bifurcation dynamics, in terms of instantaneous stretching factors, which are related to the stability of fixed points of the corresponding stroboscopic maps

[en] The metabolic effect of intratumor cholesteryl ester (CE) in breast cancer remains poorly understood. The objective was to analyze the relationship between intratumor CE content and clinicopathological variables in human breast carcinomas. We classified 30 breast carcinoma samples into three subgroups: 10 luminal-A tumors (ER+/PR+/Her2-), 10 Her-2 tumors (ER-/PR-/Her2+), and 10 triple negative (TN) tumors (ER-/PR-/Her2-). We analyzed intratumor neutral CE, free cholesterol (FC) and triglyceride (TG) content by thin layer chromatography after lipid extraction. RNA and protein levels of lipid metabolism and invasion mediators were analyzed by real time PCR and Western blot analysis. Group-wise comparisons, linear regression and logistic regression models showed a close association between CE-rich tumors and higher histologic grade, Ki-67 and tumor necrosis. CE-rich tumors displayed higher mRNA and protein levels of low-density lipoprotein receptor (LDLR) and scavenger receptor class B member 1 (SCARB1). An increased expression of acetyl-Coenzyme A acetyltransferase 1 (ACAT1) in CE-rich tumors was also reported. Intratumor CE accumulation is intimately linked to proliferation and aggressive potential of breast cancer tumors. Our data support the link between intratumor CE content and poor clinical outcome and open the door to new antitumor interventions. The online version of this article (doi:10.1186/s12885-015-1469-5) contains supplementary material, which is available to authorized users

[en] This study investigates the coupled substitution of metakaolin and limestone in Portland cement (PC). The mechanical properties were studied in mortars and the microstructural development in pastes by X-ray diffraction, thermogravimetry analysis, mercury intrusion porosimetry and isothermal calorimetry. We show that 45% of substitution by 30% of metakaolin and 15% of limestone gives better mechanical properties at 7 and 28 days than the 100% PC reference. Our results show that calcium carbonate reacts with alumina from the metakaolin, forming supplementary AFm phases and stabilizing ettringite. Using simple mass balance calculations derived from thermogravimetry results, we also present the thermodynamic simulation for the system, which agrees fairly well with the experimental observations. It is shown that gypsum addition should be carefully balanced when using calcined clays because it considerably influences the early age strength by controlling the very rapid reaction of aluminates.

[en] Differential diagnosis between dementia with Lewy bodies (DLB) and other neurodegenerative diseases with cognitive impairment represents a clinical challenge. Due to the overlapping of symptoms, the clinical diagnosis can be modified during the prolonged follow-up of these diseases. The purpose of this study was to assess the ability of cardiac metaiodobenzylguanidine (MIBG) imaging for early identification of DLB. Since January 2003, all patients with neurodegenerative diseases with cognitive impairment at their first visit at the Memory Unit and clinical criteria of DLB were consecutively recruited and underwent a cardiac ¹²³I-MIBG study. The heart-to-mediastinum ratio (HMR) and the washout rate (WR) of cardiac MIBG uptake were obtained. Sixty-five patients were included. After a clinical follow-up of 4 years, the progress of the disease procured a definite diagnosis in 44 (68%) patients: 19 DLB, 12 Alzheimer disease (AD), and 13 other neurodegenerative diseases with cognitive impairment. HMR was significantly decreased in DLB with respect to the other neurodegenerative diseases. WR was only significantly different between DLB and AD. The HMR cut off point of 1.36 differentiated DLB from the other dementias with a sensitivity of 94% and a specificity of 96% with an accuracy of 95%. Cardiac MIBG imaging performed at the time of the first clinical diagnosis of DLB can help early clinical identification or exclusion of this disease. (orig.)

[en] Microglandular adenosis is a very uncommon benign proliferative disorder of the breast that may mimic tubular carcinoma radiologically and pathologically. We describe the radiological features of this rare condition in a patient with BRCA 1 mutation. To our knowledge, this is the first case of microglandular adenosis reported in the radiology literature. The relationship between microglandular adenosis and malignancy and the association between BRCA 1 and proliferative benign disorders are also discussed. (orig.)

[en] In this explorative study, we compare national policies affecting production and use of forest-based bioenergy in five European countries: Finland, Germany, Norway, Slovenia and Spain. Our methodological approach combines horizontal and vertical policy interaction with three policy layers: policy objectives, policy instruments and thematic elements in implementation. Great variations are found in national bioenergy policies, with complex interlinkages revealed to national renewable energy and forest policies (horizontal dimension) and to EU policies (vertical dimension). Horizontally, the national bioenergy objectives are closely linked to forest policy objectives and, in Finland, also to renewable energy objectives. Policy instruments promoting bioenergy demand interact to various degrees with both renewable energy and forest policies, while supply side instruments, as well as implementation aspects, interact most closely with forest policies. Vertically, highest degree of interactions with EU polices are in this study revealed for policy objectives and instruments, less so for implementation. It is concluded that consideration of policy layers are useful for increasing the understanding of the complexity in horizontal and vertical policy interactions, and thus an important basis for understanding how to minimize conflicts and enhancing synergies among multiple forest objectives. We argue that the chosen analytical framework can enhance the understanding of complex interlinkages between bioenergy and broader policy and market developments. Identifying these complex interactions can contribute to facilitate policy developments promoting and regulating future production and use of forest-based bioenergy, while taking other forest objectives into consideration. - Highlights: • Horizontal and vertical policy interactions vary greatly across policy layers. • Bioenergy policies interact with national forest and renewable energy policies. • National bioenergy policies are influenced by EU climate and energy policies. • Policy layers help illuminate complexity in policy interactions. • Analytical framework can serve structured analysis of policy interactions

[en] Highlights: • Examines the extent to which incentive-based projects address equity concerns. • Contextual factors play crucial roles in ensuring equity and social safeguards of incentive-based projects. • FPIC process could reinforce power imbalances and inequalities. One reason for recent opposition to REDD+ stems from concerns about possible welfare impacts on forest-dependent, especially indigenous peoples. We assess how two projects with community payments (PES / REDD+) impacted indigenous peoples (Baka) relative to the locally dominant ethnic group (Bantu) in south-eastern Cameroon, trying to understand to which extent the projects addressed equity concerns. We gathered empirical data through a household questionnaire survey, indepth interviews, and focus group discussions in six villages. Overall, we found little support for the hypothesis that indigenous peoples were disadvantaged by the projects, absolutely and relative to the locally dominant ethnic group, along procedural and distributive equity dimensions. Yet, upfront contextual inequities with respect to technical capabilities, power, gender, level of education, and wealth are key to determining an individual’s likelihood of participating in and benefiting from the projects. Our analysis also revealed that more complex and time-consuming free prior informed consent processes could actually come to reinforce power imbalances and inequities. Hence, we call attention to the key role contextual factors play for equity and social safeguards when implementing REDD+ and associated interventions.