[en] Radiopharmacy is a specialized activity of hospital pharmacy related to the utilisation of RadioPHarmaceuticals (RPH). 70 pour cent to 80 pour cent of the RPH are extemporaneous preparations made the same day of utilisation. The objective of this work is to illustrate the characteristics inherent in these products to ensure safety and effectiveness. The practice of radiopharmacy begins with the radiopharmaceutical supply until its administration to the patient. Their management, preparation and quality control are intermediate stages that contribute to their efficient utilisation. The application of the rules of hygiene and radiation protection is a guarantee of efficacy and safety. My experience acquired since the establishment of the radiopharmacy in the nuclear medicine department of Sahloul hospital of Sousse, allows me to present in this work the main features of this specialty The supply of radiopharmaceuticals requires a market study followed by the choice of providers. In our department, this approach allowed a reduction of the cost of some RPH reaching 46 pour cent. The radioactive nature of these products requires careful management. In our case, this practice allowed an increase in activity of around 30 pour cent for some radiopharmaceuticals. PRH have a precise stereochemistry which gives them a very high specificity in explorations. The preparation requires, in fact strict monitoring of manufacturing procedures. The quality control of these preparations concerns the pharmaceutical and radioactive features. Indeed, patient safety and protection are the most important concerns. The development of positron emitting radionuclides with a very short physical half-life and undeniable contribution of positron emission tomography, places the radiopharmacist as one of the essential actors to the proper utilisation of PRH. The radiopharmacist in involvement at all levels of the RPH circuit. He manages orders and optimizes the utilisation of RPH. He ensures that the radiopharmaceutical administered to the patient was designed, developed and delivered with all the guarantees of safety and quality. (Author)