[en] The authors report a case of rapid ^99mTc-methoxyisobutylisonitrile (MIBI) clearance from a parathyroid adenoma. A double-phase ^99mTc-MIBI parathyroid scintigraphy was performed on a 62-yr-old female evaluated for primary hyperparathyroidism. A large parathyroid adenoma was visualized caudal to the left lobe of the thyroid gland with an unusually rapid washout of the tracer from tumor tissue. Histologic tissue examination confirmed the presence of a parathyroid adenoma and the absence of oxyphil cells. Care should be taken in interpretation of ^99mTc-MiBI parathyroid scintigrams because some adenomas can present a rapid release of the radiotracer in a double-phase study. Technitium-99m-MIBI retention could be related to the number of mitochondria-rich cells in parathyroid adenomas or to hyperplasia. 7 refs., 2 figs

[en] The authors report on a case of radiation-induced malignant Triton tumor eg malignant schwannoma with rhabdomyoblastic differentiation. The tumor was situated in the brachial plexus of a patient who had received irradiation therapy 20 years previously for breast carcinoma. Pathological and immunohistological features have been described: coexpression of PS100, vimentin and desmin indicate a common neuroectodermic origin. A review of the literature has been presented in order to evaluate the diagnostic and prognostic characteristics of this unusual tumor and its relationship to neurofibromatosis

[en] Poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme encompassing two zinc finger motifs which specifically binds to radiation induced DNA strand breaks. We develop a new immuno-labelling of poly ADP-ribose which coupled together with the immuno-detection of cells in cycle with MIB₁, permits to detect and quantify the DNA fragmentation induced by γ radiations (Cesium¹³⁷). This method, applied to organo-typical cultures of human oligodendrogliomas, submitted to γ radiation, a dose dependant nuclear signal. This one increased significantly in the presence of a radiosensitizer like iododeoxyuridine (IUDR 5 μg/ml). (authors)

[en] Purpose: To evaluate the accuracy of a 3D-endorectal 1 mm-thick slices MRI acquisition for local staging of low, intermediate and high D’Amico risk prostate cancer (PCa). Materials and methods: 178 consecutive patients underwent a multiparametric MRI protocol prior to radical prostatectomy (RP). T2W images were acquired with the 3D sampling perfection with application optimized contrasts using different flip angle evolutions (SPACE) sequence (5 mn acquisition time). Direct and indirect MRI signs of extracapsular extension (ECE) were evaluated to predict the pT stage. The likelihood of SVI (seminal vesicle invasion) was also assessed. Results: Histology showed ECE and SVI in 38 (21%) and 12 (7%) cases, respectively. MRI sensitivity and specificity to detect ECE were 55 and 96% if direct signs of ECE were used and 84 and 89% (p < 0.05), if both direct and indirect signs were combined. D’Amico criteria did not influence MRI performance. Sensitivity and specificity for SVI detection were 83% and 99%. Conclusions: 3D data sets acquired with the SPACE sequence provides a high accuracy for local staging of prostate cancer. The use of indirect signs of ECE may be recommended in low D’Amico risk tumors to optimise patient selection for active surveillance or focal therapy.