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[en] 2-Amino-1,5-dihydro-1-[methyl-2H3] 4H-imidazol-4-one ([methyl-2H3] creatinine) was obtained by acidification and heating (120oC, 120 min) of the [methyl -2H3] N-amidinosarcosine (creatine) synthesised by methylation of guanidoacetate (GA) with S-adenosyl-[methyl-2H3] L-methionine ([methyl-2H3] AdoMet) in the presence of rat liver guanidoacetate methyltransferase (GAA-MT). Isotopic enrichment was 94.7%. (author)
Journal
Journal of Labelled Compounds and Radiopharmaceuticals; ISSN 0362-4803; 
; CODEN JLCRD4; v. 31(7); p. 505-517
; CODEN JLCRD4; v. 31(7); p. 505-517