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Cherouana, Aouatef; Bouhidel, Zakaria; Boualia, Boutheina; Boualia, Boutheina; Bendeif, El-Eulmi
15. Colloquium X rays and matter. Abstract collection2023
15. Colloquium X rays and matter. Abstract collection2023
AbstractAbstract
[en] With the aim of obtaining compounds with promising properties, our team has been interested in the synthesis of aromatic Schiff bases containing triazole groups, thus combining the properties of Schiff bases with those of triazoles. A large number of bases have been obtained and studied, varying the type of triazole and/or the substituents (hydroxyl or halogen). In this contribution we present the effect of the position of the hydroxyl substituents and the type of triazole on the structure of the compound, and their antifungal properties. Four mono- and disubstituted Schiff bases will be presented, along with their structures and antifungal properties. To complete the work, a molecular docking study was carried out on the sterol 14-alpha demethylase protein (pdb: 6CR2) because of its structure, based on the design of new antifungal drugs
[fr]
Dans le but d'obtenir des composes avec des proprietes prometteuses, notre equipe s'est interessee a la synthese de bases des Schiff aromatiques contenant des groupement triazole, combinant ainsi les proprietes des bases de Schiff avec celles des triazoles. Dans ce sens un nombre consequent de bases a ete obtenu et etudie et ceci en variant le type de triazole et/ou les substituants (hydroxyle ou halogene). Nous presentons dans cette contribution l'effet de la position des substituants hydroxyle et du type de triazole sur, d'une part la structure du compose, et d'autre part, sur les proprietes antifongiques. Quatre bases de Schiff mono et disubstitues vont etre presentees avec leur structures et leurs proprietes antifongiques. Afin de completer le travail, une etude du docking moleculaire a ete realisee sur la proteine sterol 14-alpha demethylase (pdb: 6CR2) en raison de sa structure basee sur la conception de nouveaux medicaments antifongiquesOriginal Title
Effet de la position des groupements hydroxyles sur l'activite antifongique de cinq bases de Schiff de triazole. Etude structurale et docking moleculaire
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Audebrand, Nathalie (ISCR, Universite de Rennes (France)); Guinebretiere, Rene (IRCER, Universite de Limoges (France)); Guionneau, Philippe (ICMCB, Universite de Bordeaux (France)); Universite de Rennes (France); Universite de Limoges (France); ICMCB, Universite de Bordeaux (France); 216 p; Nov 2023; p. 167-168; 15. Colloquium X rays and matter; 15. Colloque Rayons X et Matiere. Recueil des resumes; Bordeaux (France); 21-24 Nov 2023; Available from the INIS Liaison Officer for France, see the INIS website for current contact and E-mail addresses; 7 refs.
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