[en] Full text of publication follows. Aim: peptide radionuclide receptor therapy is a promising treatment option in metastasized, somatostatin receptor expressing neuroendocrine tumors. A severe side effect of this therapy is radiation induced nephropathy due to renal excretion and reabsorption of the radioactive compound. In this study we investigated the influence of the dynamic scan during the injection and the importance of the following measurement time points to achieve the accumulated activity. Methods: SPECT image data and anterior and posterior planar images were acquired in 7 patients (57±14 years) at 1 h, 24 h, 48 h and 72 h after administration of Lutetium-177-DOTATATE. Furthermore a dynamic planar scan was acquired with 12 frames during the injection. Scatter correction was performed with the triple-energy window method. A co-registered CT was used for attenuation correction in SPECT OSEM reconstruction and in planar images by estimating the patient size. Total activity in kidneys were fitted to a bi-exponential function in dynamic planar images and to a mono-exponential function in SPECT and whole body planar images with the Levenberg-Marquardt-Algorithm. These functions were integrated over time to estimate the organ dose, by applying the kidney specific S value according the MIRD concept. To investigate the effect of the dynamic measurement (dyn-P) the resulting dose was compared to the same measurement without dynamics (stat-P). Furthermore we studied the influence of reducing the number of time points to the dose estimated from planar and SPECT images by omitting one of the time points 1 h, 24 h, 48 h or 72 h after injection. Results: a relative mean deviation of 3.0% was discovered by comparing dyn-P and stat-P. The Spearman Rank Correlation Coefficient (SRCC=0.87) indicated strong correlation between SPECT and planar images when all 4 time points were used. With reduced number of time points a deviation of 7.3% (1 h, 24 h, 48 h), 1.8% (1 h, 24 h, 72 h) and 3.3% (1 h, 48 h, 72 h) in SPECT and 12.9%, 12.1% and 16.2% in stat-P were observed. Conclusions: we found that dispensing with the initial dynamic measurement resulted in a relatively small error in dose calculation from planar images. The small deviation of estimated dose especially when the 72 h measurement was omitted in SPECT processing suggests a further investigation of this approach. This optimization might increase the availability of individualized peptide radionuclide therapy. (authors)