[en] Free and total prostate specific antigen (F-PSA and T-PSA) in serum were measured with immunoradiometric assay and the F/T-PSA ratio was calculated in 175 patients with T-PSA levels in the range of 4-20 μg/L. Among them 141 patients were benign prostatic hyperplasia (BPH), 23 were untreated prostate cancer (Pca untreated) and 11 were treated prostate cancer (Pca treated). The results showed that difference in F-PSA and F/T-PSA ratio for BPH group and Pca untreated group were statistically significant (P<0.01). The effectiveness of F/T-PSA ratio for Pca (89.9%) was higher than F-PSA (54.8%). The receiver-operating characteristic (ROC) curve showed an improved diagnostic efficacy of F/T-PSA ratio compared with T-PSA for discrimination between BPH and Pca. If mean F/T-PSA ratio value + 1 SE (13.2%) was used in BPH group as discrimination limits of Pca patients, the diagnostic accuracy of BPH group and Pca untreated group were 90.8% and 82.6% respectively. Thereby F/T-PSA ratio may be useful for the differentiation between BPH and prostate cancer

[en] To investigate the levels of carbohydrate antigen 19-9 in the urine samples of the patients with bladder cancer and to evaluate its clinical diagnostic value. Urine samples were taken from 30 patients with bladder cancer, 53 with benign, 22 with malignant urological diseases and 35 with malignant tumors from other systems, together with 30 normal subjects which have no any history of cancers or other urological diseases. CA19-9 was assayed by Chiron Diagnostic Corporation ACS: 180SE. The CA19-9 level of the group with bladder cancer was 159.0 +- 128.0 U/mL, while that of the group of control was 12.4 +- 8.4 U/mL. The critical points were determined as the mean value of the group of control +-1.96SD, then >28.9U/mL was considered as positive. The diagnostic sensitivity for bladder TCC were 86.7% and specificity were 68.2%. CA19-9 level in the bladder cancer group was significantly different from that of control group (P<0.001), and also different from those of other groups. The urine CA19-9 level in the group of benign urological diseases was 53.9+-77.9%, significantly higher than that of control (P=0.001), but not significantly different from those of the group of other urological cancers and other systems cancers. Preliminary study indicates that CA19-9 urine samples study is a non-invasive auxiliary index for the clinical diagnosis of bladder cancer. The method is simple and useful. But the interference fro mother benign and malignant diseases as well as gene-types should be considered in clinical practice

[en] ²⁰¹TlCl scintigraphy in 19 cases of thyroid follicular nodules after ^99mTc scintigraphy visualized a thyroid cold nodules. The results showed that ²⁰¹TlCl uptake in cold nodules of 6 cases still remained deficient. ²⁰¹TlCl uptake of 10 nodules was the same as normal thyroid tissue, whereas that of 3 nodules higher than normal thyroid tissue. The overall positivity was 13/19

[en] Serum CA-50 level was measured in 63 patients with hepatitis B(HBV) by using CA-50 IRMA kit. The results are compared with 109 normal blood donors and 11 cases of hepatocellular carcinoma(HCC). CA-50 levels of all normal persons were less than 17 U/ml(4.4 +- 6.2 U/ml), but in 63 patients with HBV, CA-50 level was higher than 17 U/ml in 48 cases (76%), while CA-50 level in HCC group was higher than normal in all the cases

[en] The refollow-up has been carried out in hypothyroidism caused by ¹³¹I treatment for Graves disease. The serum HS-TSH(IRMA), FT3, TSH(RIA), TT3, TT4, FT4I, MCA, TGA, Cholesterol and Triglyceride has been measured in 26 patient after ¹³¹I treatment for 9.5 years in average. At the same time TRH stimulation test was also performed, and the clinical symptoms and signs assessed. The results showed that TSH is the most sensitive criterion for hypothyroidism, followed by Cholesterol and FT₄I. The occurence of hypothyroidism may be related to the presence of thyroid antibody as demonstrated by the elevation of serum MCA, TGA. Therefore measurement of serum TSH, FT₄I and Cholesterol during long term follow-up is beneficial for early diagnosis of hypothyroidism and evaluating the effect of substitution treatment

[en] Radioligand binding assay of gastrin receptor (GR) was established to determine GR content and K_d of gastric cancer and mucosa in specimens of 34 patients. Both of Gs_-5 and [leu¹⁵]Gs_-17, as unlabelled ligand, can inhibit the binding of ¹²⁵I-(leu¹⁵)Gs_-17 to the membrane, and the inhibiting effect of Gs_-5 is slightly stronger than that of (leu¹⁵)Gs_-17. Mixed cellulose acetate filters have better effect to separate bound ¹²⁵I-(leu¹⁵)Gs_-17 from free ¹²⁵I-(leu¹⁵)Gs_-17 than glass fibre filters (Hongguan 999999). The GR of gastric cancer correlates with that of mucosa in the same region of 34 patients

[en] To evaluate clinical value of single or combined tumor marker detection CY21-1, CEA, CA15-3 and SCC in the diagnosis of lung cancer. There was retrospective analysis of 87 lung cancer inpatients, all of them was confirmed by pathology. Results showed: (1) Sensitivity of CY21-1, CEA, CA15-3 and SCC by single detection in diagnosing lung cancer was 59.8%, 39.1%, 44.8%, 18.4%, respectively. (2) Sensitivity of group I (CY21-1 + CEA) was 78.2%; sensitivity of group II (CY21-1 + CEA + CA15-3) was 88.5%; sensitivity of group III (CY21-1 + CEA + CA15-3 + SCC) was the same as group II. In the diagnosis of lung cancer, the combined detection with CY21-1, CEA, CA15-3 was an ideal selective combination

[en] Objective: To investigate the effect of different membrane on the clearance of serum β₂-MG in maintenance hemodialysis patients. Method: 106 maintenance hemodialysis patients randomized divided into group A and group B. Group A used cellulose triacetate membrane (N-130E), Group B used polysulfone membrane (F6). The levels of serum β₂-MG before and after hemodialysis were compared in Group A and B, respectively. Results: Before hemodialysis, the level of serum β₂-MG was not significant different between Group A and B (46.74 ± 19.46 mg/L vs 47.49 ± 16.71 mg/L, P>0.05). In Group A, compared with that before hemodialysis, the level of serum β₂-MG after hemodialysis decreased significantly. (46.74±19.46 mg/L vs 39.76 ±17.66 mg/L, before HD vs after HD, P<0.05). In Group B, there was nodifference in the levels of serum β₂-MG between before and after hemodialysis (47.49±16.71 mg/L vs 50.19±22.76 mg/L, P>0.05). Conclusion: N-130E dialyzer is better than F6 dialyzer as the effect of clearance serum β₂-MG is concerned

[en] To explore the relationship between PRL, GH(RIA), GH(RRA) serum levels changes and the onset and development of disease in patients with SLE, and to understand the hormonal changes in active and inactive phase of disease, 28 cases and 20 controls were studied. The results showed that anti-ds-DNA serum level in active and inactive phases was higher than those in controls (P<0.01) and also there was significant difference between active and inactive phase (P<0.01). Moreover, there is significant difference in PRL level between the patients in active phase and the controls (P<0.05), also in GH serum level between the patients and the controls (P₁<0.01) and the patients in inactive phase (P₂<0.05). This study indicated that the higher serum level of PRL, GH(RIA), GH(RRA) is correlated with some autoimmune characteristics of SLE, especially in its active phase. Therefore it gives some help for clinical study of SLE

[en] Radioiodinated AMT is a new positive imaging agent for brain tumour. In this paper, its radioiodination, purification, and biodistribution in mice is described. AMT was labelled with ¹²⁵I/¹³¹I using either chloramine-T or iodogen method. The labelling rate was 60% to 80%. After column chromatography on Sephadex LH-20, the radiochemical purity was greater than 98%. Animal experiments showed that ¹²⁵I-AMT was eliminated from blood rapidly and was mainly excreted through kidney. 5, 15, 30, 60 minutes after tail vein injection, the radioactivities of brain tissue per gram was 4.14%, 2.50%, 2.13%, 1.24% of injection dose respectively