[en] The aim of this work was to study of the physico properties of crosslinked poly (ethylene oxide) (PEO) hydrogel produced by gamma and its potential use for drug release in order to be applied as a wound dressing. A crosslinked PEO hydrogel was prepared in the matrix form using PEO polymer via radiation polymerization. A series of PEO hydrogels with different compositions (1-7 % w/v) at an irradiation dose of 20-40 kGy were prepared. The gel content and swelling ratio studies were conducted by gravimetry. The maximum gel content of hydrogel ∼ 95 % at a dose of 40 kGy, and the swelling ratio maximum of 10-15 g/g was reached in about 8 h at the dose of 20 kGy. Drug release experiments were performed in a continually release system using model drug (tetracycline) loaded PEO hydrogel measured by UV-Vis spectrophotometry. A specific PEO hydrogel formulation possessing the highest PEO content (7 % w/v) and loaded with 10 mg antibiotic released range of 80-90 % of the total loaded drug in 24 h at pH 7.4 in distilled water. This hydrogels could be considered as a potential candidate for antibiotic carrier in wound dressing and or transdermal applications. (author)

[en] Crosslinked poly(acrylamide) (PAAM)-co-alginate hydrogels were prepared by gamma irradiation (γ-irradiation) and their conditions such as irradiation dose and alginate concentration were studied. PAAM-co-alginate was crosslinked to yield water sorption materials with various ability to absorb water (swelling) depending on the preparation conditions (e.g. γ-irradiation dosage>20 kGy) and alginate concentration (0.5 - 1 wt %). With an increase of γ-irradiation dosage and alginate concentration, the gels content and water absorption were increasing markedly. The swelling properties of hydrogel in urea and NaCl solution and the effect of temperature were also investigated. Intensity decreasing of functional goups of OH and NH₂ in the IR spectrum indicated that IPN (Interpenetreting Network) structure occured in the network of hydrogels. The ability of hydrogel to absorp and retain a large amount of water suggested their possible uses in health care and agriculture. (author)

[en] In the order to develop application of radiation to improve the quality of natural polymers, irradiation effects on physico-chemical characterization of Na-alginate has been carried out. Both Na-alginate powder and solution were irradiated by gamma rays at doses of 0;10;30; and 50 kGy. The parameters observed consisting of viscosity, pH, tensile strength, IR and UV spectra of irradiated and unirradiated samples. The results showed that irradiation up to 50 kGy, did not give effect on pH and no new peak appeared in the IR spectra. However, tensile strength and viscosity decreased with increasing irradiation dose up 50 kGy, which showed the possibility of degradation process on Na-alginate. (author)