[en] Previous studies have showed the anticancer effect of the all-trans retinoic acid (ATRA) in many tumors including breast cancer; however, the underlying molecular mechanism is still poorly understood. This study experimentally revealed that ATRA treatment inhibited MCF-7 cell proliferation and promoted its apoptosis, along with an enhanced expression of docking protein 1 (DOK1). ATRA's effects on cell proliferation and apoptosis were prevented by DOK1 knockdown. In addition, the genetic silence of DOK1 can inhibit PPARγ expression and its activity. Moreover, inactivation of PPARγ by its specific inhibitor GW9662 reversed the impacts of ATRA on cell proliferation and apoptosis. Taken together, these results indicate that ATRA-enhanced expression of DOK1 activates PPARγ leading to inhibition of cell proliferation and enhancement of cell apoptosis in MCF-7 cell. - Highlights: • ATRA treatment inhibited MCF-7 cell proliferation, along with an enhanced expression of docking protein 1 (DOK1). • The genetic silence of DOK1 can inhibit PPARγ expression and its activity. • Inactivation of PPARγ by its specific inhibitor GW9662 reversed the impacts of ATRA on cell proliferation. • ATRA-enhanced expression of DOK1 activates PPARγ leading to inhibition of cell proliferation in MCF-7 cells.

[en] To explore the effectiveness and safety of the patients with coronary heart disease after coronary intervention therapy. 140 patients with coronary heart disease hospitalized and randomly divide them into observation group and control group with 70 patients respectively. Give coronary intervention therapy to the 70 patients in the observation group, and give drug therapy to the 70 patients in the control group. Compare the overall effective rate, survival rate and occurrence probability of complications of the two groups. The overall effective rate of patients in observation group reaches 92.86%, while the rate of patients in the control group only reaches 81.43%. Through data comparison of these two groups, it is found that the overall effective rate of the control group is far less than that of the observation group, so does the survival rate within 1 year; the differences between the two groups are statistically significant (P<0.05). although the occurrence probability of complications of the observation group is less than that of the control group, their difference is not statistically significant (P>0.05). The effect of coronary intervention therapy for patient with coronary heart disease is better than the effect of drug therapy, and both therapies have equivalent safety. Practical Application: The treatment effect of coronary intervention therapy on Coronary heart disease CHD patients is better than that of the drug therapy, and both therapies have equivalent safety. (author)

[en] Modification of low-density polyethylene (LDPE) by grafting it with a maleic anhydride (MAH) was conducted using a co-irradiation technique at room temperature under a vacuum atmosphere at absorbed doses of 10 kGy, 25 kGy, 50 kGy, and 100 kGy. The effects of the absorbed dose on the chemical structure and physical properties of LDPE-g-MAH were investigated. The Fourier transform infrared spectroscopy showed that the MAH was grafted onto the LDPE surface successfully. The grafting degree of the MAH increased with the absorbed dose. The melting temperature (Tm) and thermal degradation temperature (T5%) of the LDPE-g-MAH films decreased with the increasing absorbed doses because of the occurrence of crystal defects of LDPE caused by irradiation. However, the morphologies and crystal forms of LDPE did not change after irradiation. This work provides an effective strategy for radiation graft modification of LDPE. (authors)

[en] Gallium arsenide (GaAs) nanowire array (NWA) photocathodes have unique electrical and optical properties. Based on studies about photon absorption, band structure, and electron transport properties of GaAs nanowire, a photoemission model for GaAs NWA photocathodes is established. According to the model, we simulate and analyze the photocurrent, spectral response, and absorption properties of ordered GaAs NWA photocathodes. The results present a very interesting phenomenon; the photocurrent and spectral response peak at incident angles of 20° and 30°, respectively. These special properties of NWA cathodes differentiate them from their thin film counterparts. We also analyze the effects of nanowire length and diameter on the photocurrent of NWA cathodes, and find the optimum height of the nanowires is 10 μm. This study shows that NWAs exhibit higher absorbance and excellent charge transport. Thus, GaAs NWA photocathodes are excellent candidates for electron sources. (paper)

[en] Conventional textile dyeing industries use small molecular weight organic dyestuffs, where the unreacted dyestuff molecules generate large quantities of refractory wastewater and cause serious problems to the environment. This highlight reports on the latest article for textile dyeing through the radiation-induced graft polymerization (RIGP) method, where carbon-carbon double bond functionalized nanoparticles including carbon black, cobalt blue, cobalt green, and iron red were immobilized on the surface of cotton fabric. The wastewater generated in this process can be discharged directly, as the concentrations of the contaminants are lower than those of the international standard and Chinese national standard requirements. The fastness of the color is ensured by the covalent bonding between the nanoparticles and the cellulose macromolecules, which remains unchanged after 100 domestic laundering cycles. (authors)

[en] Ionizing radiation is a promising method for dye degradation or textile coloration using commercial azo dyes and small molecular weight organic dyes. Thus, the stability of the molecular structure of an azo dye is important under ionizing radiation. Disperse Blue 79, as an example azo dyes, was irradiated with gamma rays or electron beam (EB) to investigate the radiation-induced effects on the molecular structure. Ultraviolet visible spectroscopy (UV-Vis), nuclear magnetic resonance (NMR) spectra analysis, and mass spectrometry (MS) studies indicated that acetoxy and methoxyl were easily cleaved on the irradiation of the aqueous dye solution but retained a stable structure on the irradiation of the powder form. Gamma rays and EB showed similar effects on the decomposition process. Chromaticity changes using the Lab^* method showed that the dye turned to dark yellow and the value of b^* of the irradiated dyes increased with the increasing absorbed dose, which indicated that Disperse Blue 79 could be partly decomposed in an aqueous solution with an absorbed dose of 10 k Gy. Furthermore, the results demonstrated that the chemical stability of the Disperse Blue 79 under ionizing radiation are different in its powder form with the dye in the aqueous solution. (authors)