[en] Highlights: • China focusing increasingly on joint operation of cascaded hydropower stations. • Investigating the increased power generation potential of joint cascade operation. • Dynamic programming algorithm and super-computing avoid dimensionality problem. • Optimizing reservoir operation yields greater gains than joint operation. • Growing water and energy demands require careful construction of station clusters. The completion of Shuibuya, the last hydropower station to be constructed in the Qingjiang cascade, signifies China's successful development of the world's largest mixed cascade hydropower generation system. Joint operation of such cascaded hydropower stations is considered necessary to improve hydropower output in China. In this study, two modeling methods – routine and optimal operations – were adopted, based on existing rules of reservoir operation, to determine the effects of joint operation. To investigate the realistic and potential effects, the two models were computed using observed runoff data (1951–2009). The potential effects were identified by comparing the total hydropower generation two single cascades and their cogeneration. Under the routine operational mode, the incremental power generation of joint operation would be 5.73 × 10⁸ kWh, an increase of 5‰ compared to isolated operation. However, even in isolation, if reservoir operation is optimized through the dynamic programming algorithm, the incremental power generation of the cascade would be 42.24 × 10⁸ kWh, which is seven times that of joint operation with routine reservoir operation (5.73 × 10⁸ kWh). The results showed that, under current reservoir operating rules, there is little room for improvement in hydropower generation, although joint operation could increase hydropower generation to a certain extent, especially in the reservoirs' refill and release stages. China must amend its existing operational mode for reservoirs to enhance the economic benefits of cascade hydropower stations. Furthermore, to meet increasing demands for both water and energy, carefully considered planning of constructing clusters of these stations is required.