[en] In this study the radioiodination process of meta-iodobenzylguanidine with ¹³¹I isotope in presence of ammonium sulphate and Cu(II) Catalyzer was investigated. In order to optimize the process, the influence of different parameters on labeling yield was studied. The results of experiments showed that the use of oil bath with temperature of 160^degree^C is necessary. After the labeling process, purification step of the final product was carried out using Dowex-1 x 8 resin. The mean labeling yield was 97.2^percent^. In this method radiolabelling of MIBG with ¹³¹I (185 MBq for diagnostic dose and 3330 MBq for therapeutic dose) is quite simple and it complies with the requirements of routine production of ¹³1I-MIBG radiopharmaceutical for diagnostic and therapeutic purposes. This paper is a narration of industrial scale production of ¹³¹I-MIBG radiopharmaceutical.

[en] Zirconium molybdate gel has an excellent characteristic to be used as a column matrix material of ⁹⁹Tc generators. The preparation conditions of zirconium molybdate gels will directly influence their physico-chemical characteristics and thus generator performances. In this work a series of zirconium molybdate gels were synthesized under different conditions and characterized by inductively coupled plasma, thermo gravimetric analysis , XRD and scanning electron microscopy Techniques. The effects of different parameters including p H of molybdate solution, Zr:Mo molar ratios, order of reactants addition, washing and granulating of gel on the performance of technetium-99m generators were evaluated. The experiments show that the optimum conditions for synthesis of the gel consist of: p H=4-4.5, Zr:Mo ratio of 1:1, gradual addition of molybdate solution to zirconium oxy chloride solution, no washing and grinding the resulted gel.

[en] ^99mTc can be produced from ⁹⁹Mo/^99mTc gel generators. These gels are part of the generator and the ⁹⁹Mo/^99mTc gel generator performance is directly related with gel structure. In this work a series of zirconium molybdate gels have been synthesized and dried under different conditions and characterized using thermal analysis (TGA, DTA), SEM, XRD and porosity measurements. It is found that the water content of the gel determines the structure porosity which allows the diffusion of the ^99mTcO₄^- ions inside the gel and was directly connected with performance of the ⁹⁹Mo/^99mTc gel generators. Drying conditions of the gel is as an important factor that influence water content and physical-chemical properties of this gel and must be carefully studied to optimize the properties of the gel generators.