[en] Ultraviolet photoelectron spectra for W_nN₂^- (n=1-8) clusters produced by addition of atomic and molecular nitrogen on W anion clusters are presented. Evidence is provided that molecular chemisorption of N₂ is more stable than the dissociative one on tungsten anion clusters consisting of eight atoms or less, which is completely different from the results on tungsten bulk surfaces. A general tendency toward molecular chemisorption for small clusters can be explained by reduced charge transfer from the metallic d-orbitals of cluster in contrast to bulk d-orbitals. Comparative studies on chemisorption of atomic and molecular species of diatomic molecules on nanoclusters are expected to provide important information on size-dependent changes of chemical properties of nanoclusters

[en] Experimental and theoretical evidence is presented for the nondissociative chemisorption of O₂ on free Au cluster anions (Au_n^-, n=number of atoms) with n=2, 4, 6 at room temperature, indicating that the stabilization of the activated di-oxygen species is the key for the unusual catalytic activities of Au-based catalysts. In contrast to Au_n^- with n=2, 4, 6, O₂ adsorbs atomically on Au monomer anions. For the Au monomer neutral, calculations based on density functional theory reveal that oxygen should be molecularly bound. On Au dimer and tetramer neutrals, oxygen is molecularly bound with the O-O bond being less activated with respect to their anionic counterparts, suggesting that the excess electron in the anionic state plays a crucial role for the O-O activation. We demonstrate that interplay between experiments on gas phase clusters and theoretical approach can be a promising strategy to unveil mechanisms of elementary steps in nanocatalysis

[en] We present the first direct N${}_f$=2 lattice QCD computation of two- and three-π${}^{+}$ scattering quantities that includes an ensemble at the physical point. We study the quark mass dependence of the two-pion phase shift, and the three-particle interaction parameters. We also compare to phenomenology and chiral perturbation theory (ChPT). In the two-particle sector, we observe good agreement to the phenomenological fits in s- and d-wave, and obtain M${}_{\mathrm{\pi <!--\; ??\; -->}}$$a_0$ = -0.0481(86) at the physical point from a direct computation. In the three-particle sector, we observe reasonable agreement at threshold to the leading order chiral expansion, i.e. a mildly attractive three-particle contact term. In contrast, we observe that the energy-dependent part of the three-particle quasilocal scattering quantity is not well described by leading order ChPT.

[en] Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma tumours were associated with clinically different phenotypes. However, such data is still rare for important patient subgroups, such as patients with MYCN non-amplified advanced stage disease. Prediction of the individual course of disease and optimal therapy selection in this cohort is challenging. Additional research effort is needed to describe the patterns of gene expression in this cohort and to identify reliable prognostic markers for this subset of patients. We combined gene expression data from two studies in a meta-analysis in order to investigate differences in gene expression of advanced stage (3 or 4) tumours without MYCN amplification that show contrasting outcomes (alive or dead) at five years after initial diagnosis. In addition, a predictive model for outcome was generated. Gene expression profiles from 66 patients were included from two studies using different microarray platforms. In the combined data set, 72 genes were identified as differentially expressed by meta-analysis at a false discovery rate (FDR) of 8.33%. Meta-analysis detected 34 differentially expressed genes that were not found as significant in either single study. Outcome prediction based on data of both studies resulted in a predictive accuracy of 77%. Moreover, the genes that were differentially expressed in subgroups of advanced stage patients without MYCN amplification accurately separated MYCN amplified tumours from low stage tumours without MYCN amplification. Our findings support the hypothesis that neuroblastoma consists of two biologically distinct subgroups that differ by characteristic gene expression patterns, which are associated with divergent clinical outcome

[en] Extracorporeal cardiopulmonary resuscitation (eCPR) may be considered as a rescue attempt for highly selected patients with refractory cardiac arrest and potentially reversible aetiology. Currently, there are no randomised, controlled studies on eCPR. Thus, prospective validated predictors of benefit and outcome are lacking. Currently, selection criteria and procedure techniques differ across hospitals and standardised algorithms are lacking. Based on expert opinion, the present consensus statement provides a first standardised treatment algorithm for eCPR.