[en] Mice treated with Cyclophosphamide (Cy) shortly before inoculation of influenza A virus exhibited increased mortality and delayed mean time of death. The extrapulmonary dissemination of the infection was observed more often in Cy-treated animals with the titres of virus in different organs substantially higher than in equally infected immunocompetent controls. Although the humoral antibody response was not impaired in Cy-treated mice, they were more susceptible to challenge with a lethal dose of virus than normal animals. In X-irradiated mice, the increased multiplication of virus in lungs and spread of the infection to other organs was observed, with prolonged persistence of virus in lungs and brains as compared to adequate controls, reminding of previous observation in immunocompromised persons, who died in the course of influenza. (author) 1 fig., 4 tabs., 23 refs

No abstract available

[en] Care for patients with Alzheimer's disease (AD) and other cognitive disorders has been fragmented in the Czech Republic and unevenly and inadequately accessible in different regions. Neurologists, psychiatrists, geriatricians and general practitioners are involved in treatment. The aim of the implementation of the National Action Plan for AD and Similar Diseases 2020-2030 (NAPAN), approved by the Government of the Czech Republic, is to establish a single recommended approach for the diagnosis and treatment of patients with AD and similar diseases, so that the patient always receives good comprehensive care, regardless of the consulted specialist and the concerned region. These recommended practices include also an effort to define the system of care, to define the role and set up cooperation between the various specialties and to create a network of care ensuring the availability of all the above-mentioned specialties and specialized centers for management of AD patients. (author)