[en] Complete text of publication follows. Thermo and pH-responsive gels have received much interest in different fields of knowledge for their applications in drug delivery systems, controlled release systems for targeted delivery to specific areas of body and others. Poly(acryloyl-L-proline methyl ester) (A-ProOMe) exhibits a lower critical temperature (LCST) of 14 deg C and polyacrylic acid (PAAc) exhibits a critical pH response at about 4.5 deg C. In this work, three different systems containing (A-ProOMe) and (PAAc) were synthesized by gamma radiation; a) A-ProOMe grafted onto PAAc hydrogel 'comb type hydrogel'; b) radiation binary grafting of A-ProOMe and AAc onto PP by mutual irradiation method PP-g-AAc/A-ProOMe; and c) and binary grafting of those monomers in two step radiation method (PP-g- AAc)-g-(A-ProOMe). The characterization of the graft copolymers was examined by infrared (FTIR-ATR), and thermal analysis (TGA). Limit swelling behavior, pH sensitivity and Cu⁺² uptake of different systems will be discussed. The authors wish to express their thanks to S. Castillo-Rojas, B. Leal, F. Garcia, and M. Cruz, from ICN-UNAM, for technical assistance. This work was supported by DGAPA-UNAM Mexico, Grant IN200108.