[en] Objective: To study the changes of leptin levels in females with abnormal thyroid function. Methods: Serum leptin levels were determined with RIA in 60 cases of hyperthyroidism, 36 cases of hypothyroidism and 30 normal controls. In patients with thyroid dysfunction and treated, serum leptin levels were again measured after completion of therapy. Results: The serum leptin levels were positively correlated to BMI in all the cases (p < 0.01). The serum leptin levels in patients with hypothyroidism (4.21 ± 1.87 μg/L) were significantly lower than those in healthy subjects (8.18 ± 3.31 μg/L) (p < 0.01). There were no statistical differences between the values in patients with hyperthyroidism (8.61 ± 3.04 μg/L) and normal subjects (p > 0.05). The serum leptin levels in hypothyroid patients after treatment (6.77 ± 2.35 μg/L) were significantly higher than those before treatment (4.19 ± 1.84 μg/L) (p < 0.05). No obvious differences in the levels of serum leptin were observed before and after treatment in the hyperthyroid group. Conclusion: Normal thyroid hormone levels may be an important factor to achieve an adequate leptin gene expression so as to maintain an energy metabolic balance and thyroid dysfunction will influence the normal regulation of leptin

[en] This paper summarizes the requirement of X-ray pulsar navigation and the development of X-ray detector. The difficulties of pulsar navigation in space environment are pointed out. The lack of detectors in terms of detection efficiency, time resolution and load is discussed. Finally, some suggestions are given for future research in X-ray pulsar navigation. (paper)

[en] Lung cancer is the most common malignancy in China, and its morbidity and mortality have been increasing every year. MR functional imaging includes diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI), intravoxel incoherent motion (IVIM), dynamic contrast-enhanced (DCE), arterial spin labeling (ASL), and MR spectroscopy, etc. It not only can assess tumor morphologic characteristics, but also can quantify tumor various objective indexes. MR functional imaging has a certain significance to identify benign tumor and malignant tumors, different pathological types, different lung cancer staging, and so on. In this review, we focus on the MR functional imaging for lung cancer. (authors)

[en] Novel N-n-butyl-1,8-naphthalimide derivatives with mono- or di-substitution to the C-4 position containing a N atom and a carbonyl have been synthesized as a efficient silver(I) fluorescent sensor. The ligand structures were confirmed by IR, NMR, MS, and elemental analysis. A highly sensitive spectrofluorometric method based on chelation-assisted fluorescence quenching was developed for trace-level detection, estimation and speciation studies of silver(I) in ethanol-water. The ligand exhibits emission and excitation maxima at 525 nm and 420 nm, respectively. The novel fluorescent sensor exhibited selective binding toward Ag(I) and pH insensitivity over a biologically relevant range. The interference of foreign ions was observed to be negligible.

[en] At present, the analytical method (reliability prediction) is mainly used to calculate the equipment reliability of electronic equipment system. But reliability verification and evaluation of electronic equipment, which is highly reliable, needs a lot of time and economic costs. In this paper, a reliability simulation algorithm based on Monte Carlo method is proposed to verify and evaluate the reliability of highly reliable GNSS receiver. Which can meet the requirements and greatly reduce the project cost. (paper)

[en] Objective: To study the influence of ¹³¹I treatment on the circulating sFas levels of patients with Graves' disease (GD) before and after treatment with ¹³¹I. Methods: Using the method of enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay, the levels of sFas in serum and thyroid hormone of GD 52 patients were measured before and after ¹³¹I therapy while 30 healthy subjects with age and sex matched served as controls, and the results were compared with that of the control group. Results: The sFas levels in serum of GD patients were significantly higher than that of the control group (P<0.01). The serum sFas level tended to decrease after the medication of ¹³¹I at 180 d, but still higher than that of the normal controls (P<0.05). The concentration of serum sFas was positively correlated with the titers of anti-hyrotropin (TSH) receptor antibody (r=0.595, P<0.01), but not with the other clinical parameters (FT₃, FT₄ and TSH). Conclusions: Abnormal concentration of sFas in serum can be observed in patients with GD. ¹³¹I therapy would suppress the auto-immune status in GD patients, and the circulating sFas may play a role in the pathogenesis of GD. (authors)

[en] The formation and control method of coolant free surface is one of the key technology for the design of windowless target in Accelerator Driven System (ADS). In recent study, experimental and CFD investigations on free surface behavior are performed in a scaled windowless target model by using water as test fluid. The method of laser light sheet is applied for visualization of the flow field. Experiments are carried out at various Reynolds numbers. The structure and features of the flow vortex are investigated. In addition, CFD simulation is performed by using both Fluent and OpenFOAM platform. The effect of different turbulence models, such as k-ω model, Reynolds stress model and LES model, on the velocity profile and free surface behavior are tested. The numerical results of LES model agree qualitatively well with the experimental data related to both flow field and free surface behavior. (authors)

[en] Recently antibiotics wastewater in environment has induced the increment of bacterial resistance. This paper is to investigate the gamma radiolysis of wastewater containing 10 μg/mL levofloxacin lactate (LVF). It has been found that the antibiotic was removed more than 99% with 1 kGy under air while the G-value decreased with the dose increment.Five main degraded products (m/z 346, 330, 318, 302, 274) and the most probable radiolysis pathway were identified by liquid chromatography-mass spectrometry (LC-MS). Compared with the degradation under N₂, the radiolytical mechanism was suggested.In the active assay, 2 μg/mL was the inhibitory concentration.Compared with the concentration of 4 μg/mL, the minimal inhibitory concentration (MIC), degraded products analysis can be suggested that the byproduct m/z 346 might have the anti-E. coli activity. It has been shown that 3 kGy is the appropriate dose for the radiolytical treatment of LVF. To sum up, the gamma radiation technique is an effective method for decomposing antibiotics, and it is necessary to take the activity of degraded products into consideration. (authors)

[en] Transient boiling heat transfer is important to the safety of nuclear reactors. Reactivity insertion accidents (RIA) in a nuclear reactor might result in a power excursion in which the heat generation in the fuel rises exponentially with time. The period of the exponential power excursion depends upon the magnitude of the reactivity insertion. The heat generated within the fuel is transferred to the water coolant which then starts to boil. The reactivity feedbacks caused by the heating (Doppler in the fuel and void in the coolant) represent an important mitigation mechanism for such accidents. The time delay between heat generation in the fuel and its transfer to the coolant is key to determining the outcome of the accident, in particular for experimental reactors using highly enriched fissile fuel with a very low Doppler effect. This time delay depends on conduction heat transfer within the fuel, single-phase convective heat transfer and eventually transient boiling heat transfer in the coolant. Although existing transient boiling databases form a highly valuable source of information, sometimes conclusions from different authors are quantitatively and qualitatively in disagreement with each other. This is likely due to differences in experimental setups and also limitations in the accuracy of diagnostics available in those experiments. In order to clarify these discrepancies and shed light on the mechanisms of transient boiling heat transfer, a new experimental study of both pool and flow boiling under exponential power input were carried out respectively. Exponential power escalation periods from 5 ms to 100 ms, bulk temperatures from saturation to 75 K of subcooling and Reynolds number from 25000 to 60000 have been explored at ambient pressure in both pool and flow boiling conditions. What makes this study unique is the use of synchronized state-of-the-art diagnostics such as IR thermometry and high speed video (HSV) which has improved the accuracy of measured quantities, and has provided a new and unique insights into the transient boiling heat transfer, including detection and modeling of the onset of nucleate boiling, better understanding of the transient boiling process and revelation of a new heat transfer mechanism that leads to higher CHF. (authors)

[en] Positron emission tomography/magnetic resonance imaging (PET/MRI), as a new hybrid imaging tool, has not been fully studied. Considering the priority of MRI to CT, such as high soft tissue contrast, no ionizing radiation, multiparameters imaging, and capability of providing more function information, the combination of PET and MRI may have greater potential in lung cancer than PET/CT. In this review article, the different PET/MRI systems are introduced briefly. The potential application of PET/MRI in lung cancer are mainly described in terms of detection of lung nodule, differential diagnosis of lung nodule, TNM staging, prognostic prediction, therapeutic response evaluation, and recurrence detection. (authors)