[en] Highlights: • HAIC shows great effecacy in the treatment of unresectable hepatocellular carcinoma. • The nomogram accurately predicts the survival of patients after HAIC. • Our prognostic model is superior to the conventional staging systems. Hepatic arterial infusion chemotherapy (HAIC) has shown encouraging efficacy in the treatment of hepatocellular carcinoma (HCC). This study aims to establish and validate a novel nomogram to predict individualized survival outcomes for patients with unresectable HCC after HAIC.