No abstract available

No abstract available

[en] The specific binding of 125I-labeled eel growth hormone (eGH) to liver membranes of the eel was examined. The specific binding to the 10,000g pellet was greater than that to the 600g pellet. The specific binding was linear up to about 100 mg fresh tissue, and was saturable with increasing amounts of membrane. The specific binding was pH-, temperature-, and time-dependent, with the optimum pH at 7.4, and greater specific binding was obtained at 15 and 25 degrees than at 35 degrees. Scatchard analysis of liver binding gave an association constant of 1.1 x 10(9) M-1 and a capacity of 105 fmol/mg protein. The receptor preparation was highly specific for GHs. Natural and recombinant eel GHs as well as recombinant salmon GH competed equally with 125I-eGH for the receptor sites of the 10,000g liver membrane. Ovine GH was more potent in displacing the labeled eGH than the homologous eel hormone. Tilapia GH and ovine prolactin (PRL) were needed in greater amounts (40 times) than eGH to displace the labeled eGH. Salmon and tilapia PRLs were still less potent (500 times) than eGH. There was no displacement with eel PRL. No significant change in the specific binding was seen 1 week after hypophysectomy, whereas injection of eGH into the hypophysectomized eel caused a significant reduction after 24 hr. The binding to the membrane fractions from gills, kidney, muscle, intestine, and brain was low and exclusively nonspecific, indicating the presence of specific GH receptors predominantly in the liver

[en] The term ''unevenness'' of the lung images has been used rather vaguely in perfusion and inhalation studies. The ''unevenness'' on lung perfusion images often indicates the presence of chronic obstructive pulmonary diseases, whereas the peripheral and central patterns on aerosol inhalation lung images are seen in chronic bronchitis and pulmonary emphysema, respectively. The modes of display to express ''unevenness'' on lung images are: 1. profile display, or one-dimensional display on any single line on the image; 2. contour and/or numerical display, or two-dimensional display; and 3. three-dimensional display. These are, however, nothing but qualitative expressions. The purpose of the present study was to numerize the ''unevenness'' on images, especially of lung perfusion and inhalation images and to see if there were any characteristic features among disease entities by making a comparison between these parameters of ''unevenness'' and the data of lung function tests

No abstract available

[en] A comparative study was made of the effects of 15 synthetic and naturally occurring flavonoids on the hydrolytic activity of Na⁺, K⁺ -adenosine triphosphatase (ATPase). Twelve of the flavonoids examined were mono-hydroxy or mono-methoxy derivatives. All inhibited Na⁺, K⁺ -ATPase from dog kidney cortex when present at concentrations from 40-1000 μM. Flavones possessing cyclohexyl instead of the phenyl group were the most potent with IC₅₀ at 257-320 μM. Structure-activity relationships were observed among the following mono-substituted flavones as: (i) 2-cyclohexyl-benzopyran-4-one much-gt 2-phenyl-benzopyran-4-one; (ii) 2-cyclohexyl-7-hydroxybenzopyran-4-one > 2-cyclohexyl-6-hydroxy-benzopyran-4-one > 2-cyclohexyl-5-hydroxybenzopyran-4-one. Some flavonoids showing potent inhibitory activity were also examined for ouabain-displacement activity on human erythrocytes. Hardly and of the flavonoids were able to block [³H] ouabain binding to erythrocytes. These results suggest that the mechanism by which flavonoid block Na⁺, K⁺ -ATPase is not related to the cardiac glycoside-specific binding site(s) of this enzyme

[en] HAKUCHO observation of Cyg X-2 over 40 days did not show a correlation between the hardness ratio and the intensity predicted for dwarf X-ray sources. The energy spectrum in the range 0.3 - 20 keV was found to deviate from the thermal bremsstrahlung spectrum below 2 keV. The X-ray spectrum can be accounted for in terms of the Comptonization of blackbody radiation emitted from the neutron star surface and the accretion disk. 10 references

[en] Very-low-density lipoprotein (VLDL)-triglyceride (TG) kinetics were examined in rats maintained on either chow and water (control) or chow and a 10% carbohydrate drinking solution (fructose or glucose). The hexose solutions were available for an acute (16 h) or chronic (14 day) period. The acute fructose (AF), acute glucose (AG), and chronic fructose (CF) groups were hypertriglyceridemic (HTG) compared with control. Plasma TG concentration in chronic glucose (CG)-fed rats was similar to control. VLDL-TG was endogenously radiolabeled in donor rats with [2-3H]-glycerol. The fractional catabolic rate (FCR) was then determined by monitoring the clearance of plasma [3H]VLDL-TG in recipient animals. Donors and recipients were treated in an identical manner. AF and CF groups had an FCR significantly lower than rats given glucose for comparable periods. Both fructose groups and the AG group also had a lower FCR than control. In contrast, FCR in the CG group was significantly higher than controls. TG production rate (TGPR) in both AF and CF fed rats did not significantly differ from controls, suggesting that the HTG observed in these animals was solely from a catabolic defect. AG- and CG-treated glucose animals both had TGPR significantly higher than controls. Therefore, overproduction of VLDL-TG contributed to the HTG associated with this carbohydrate

[en] We can establish a new picture, the perfect fluid sQGP core and the dissipative hadronic corona, of the space-time evolution of produced matter in relativistic heavy-ion collisions at RHIC. It is also shown that the picture works well also in the forward rapidity region through an analysis based on a new class of the hydro-kinetic model and that this is a manifestation of the rapid increase of the entropy density in the vicinity of QCD critical temperature, namely, deconfinement. (orig.)

[en] We give a short review about the hydrodynamic model and its application to the elliptic flow phenomena and the pion interferometry in relativistic heavy ion collisions. (author)