[en] MM46-tumor or Ehrlich-tumor inoculated in the thigh of the C3H/He mice were subjected to local electron-irradiation at the dose of 1,000, 2,000, 3,000 or 4,000 rad, and the other, which served as the unirradiated control. The mice were killed on days 1,3,5,7,10,14 after irradiation, and resected tumor tissues were examined histologically and enzymatically. A half number of MM46-tumor bearing C3/He mice was administered dexamethasone intraperitoneally. The tumor-bearing mice with or without administration of dexamethasone were subjected to local electron irradiation at the dose of 2,000 or 3,000 rad, and the others were not irradiated. Lymphocytic infiltration was definitely observed about on day 7 with no relation to irrradiation dose and transplanted tumor species, and later, plasma cells and fibroblasts more infiltrated around tumor cells. In correlation with irradiated dose, the most intensive lymphocytic infiltration was observed in the group exposed to 2,000 rad in MM46-tumor bearing mice, and 3,000 rad in Ehrlich-tumor bearing mice respectively. Characteristic discrete granules were observed in the cytoplasms, and the lymphocytes which infiltrated the area around the tumor tissue were identified as T-cells, histoenzymatically. In the groups with administration of dexamethasone stromal lymphocytic infiltration was scarcely found, where as plasma cells and histiocytes were relatively more infiltrated. It is concluded that there would be an optimal dose for the most effective immunological resistance against topical tumor cells, and dexamethasone suppressed the local immune response. (J.P.N.)

[en] Ten patients with hepatoma who had received radiotherapy for their metastatic sites have been reviewed. In 13 lesions of bone metastasis in 7 patients complete pain relief from 5 lesions (38 %) was achieved, while partial relief (54 %) was obtained in other lesions. Of 3 patients with a brain metastasis, one attained complete symptomatic improvement with a 65 % tumor reduction, and one of the remaining two gained a symptomatic palliation. In a patient with two pulmonary metastases, intraarterial chemotherapy showed a more remarkable effect when treatment was combined with radiotherapy than intraarterial chemotherapy alone. It may be concluded that radiation therapy is effected modality for palliating metastatic lesions of hepatoma. (author)

[en] This paper deals with MRI utilization for planning radiation therapy. There have been several reports with the same purpose, however, seem to be incomplete. Such a clinical trial should basically require the high diagnostic quality of MRI for demonstrating cancer invasion. To reach the goal, we have been working with MAGNETOM H15 and/or M10 (Siemens) newly installed in Tenri Hospital. The clinical series consists of 12 patients with head and neck tumors, and with malignancies involving the mediastinum or lung apeces. The practical method and procedure are as follows. (1) The radiation field on the patient's skin is prearranged to include the tumor in its depth. This is identified by putting markers of our own making, small plastic tubes plugged with 'cheese', at each corner on the skin. The material used is based on a specificity producing high intensity signals on T₁-weighted image. (2) MR scan is performed from the skin to the depth of lesion with sequential 10 mm-slices by using T₁-weighted imaging. MRI display is on the coronal or sagittal views usually vertical to the beams of radiation therapy. (3) Of all MRI acquired, several images are used for drawing the radiation field, and one of others for the optimal demonstration of the lesion. Thus, MRI can be superimposed with the radiation field on the CRT screen. These procedures only requires 30 minites or less. (author)

[en] High-resolution CT (HRCT) of twenty patients with diffuse panbronchiolitis was reviewed to evaluate the correlation with the stage and pulmonary function. The most basic finding was diffuse small nodules, observed in all twenty patients. Of all HRCT findings diffuse small nodules correlated with %FEV 1 and PaO₂ (p < 0.05). Tram line or ectatic change of peripheral airways correlated with PaO₂ and PaCO₂ (p < 0.05). Multivariate analysis among HRCT features concerning the stage showed that involvement of thin subpleural area (SSA) was the most contributory finding (partial cor. = 0.70830) to the advanced state (stage 3) with statistically significant difference (p < 0.05). The finding concerned with such spared thin subpleural area is an important diagnostic clue in stage 3 as well as a clinical evidence of infection with Pseudomonas aeruginosa. According to this review, HRCT is considered to be an effective and promising modality in the evaluation of diffuse panbronchiolitis. (author)

[en] HRCT was carried out in twenty patients with diffuse interstitial pneumonia: 13 cases of IIP, 3 of BOOP, 2 of drug-induced pneumonia, 1 of rheumatoid lung and acute interstitial pneumonia of unknown origin. With special attention to inflammatory activity, the patients underwent HRCT periodically during the treatment. Correlative investigation between HRCT image and grade of accumulation in ⁶⁷Ga scintigraphy was also performed. Response to steroid therapy was clearly reflected on HRCT image, that was shown as decreasing pulmonary density or thinning of honeycomb wall. HRCT is considered to be useful in assessing the activity of diffuse interstitial pneumonia. (author)

[en] Ten cases of pulmonary oil embolism after lymphangiography were examined by high resolution CT. Ground glass densities or occasional pathy densities were observed throughout lungs in all cases and fine nodular opacities in addition were also noted in seven cases. These findings were compatible with those of pathological examinations and plain chest X-rays. (author)

[en] CT appearances of replaced right hepatic arteries (RRHA) were reviewed in 51 cases combined with arteriography. The demonstration of RRHA depends on its anatomical characteristics (diameter and course of the vessel) and enhancing technique of contrast media. Both poor enhancement of contrast and discontinuity of transaxial images cause troubles in identification of RRHA. For this purpose, incremental dynamic CT is the best choice and might be added to conventional CT examination. (author)

[en] To improve the diagnostic potentiality of CT for esophageal cancer, we propose a new regimen including incremental dynamic method throughout the regional lymph nodes as well as the primary lesion. This is supported by Somatom DRH, enabling 25 contiguous scans of 3-sec-scan and 3-sec-interval with 8 mm in thickness, and Medrad MARK IV with Flow Module Option. Of 9 patients with esophageal cancer 6 were estimated to have local invasion (A₃) and other 6 were involved with regional lymph node metastases (N₂-N₄). Our preliminary report suggest that such a sophisticated use of CT will provide further informations for surgery or radiotherapeutic planning. (author)

[en] We had demonstrated in the former investigation that the strongest local infiltration of T-lymphocytes was observed in C3H/He mice transplanted MM46 at seven days after irradiation with the dose of 2,000 rads. This result indicated that the enhancement of the antigenicity of tumor cells was attained after low-dose-irradiation. We had also reported that specific active immunotherapy using low-dose-irradiated tumor cells and activated mononuclear cells after radiotherapy was effective on the elongation of survival period. In this paper, we studied whether the tumor cell inoculated after active specific immunotherapy was inhibited or not. Active specific immunotherapy using tumor cells and mononuclear cells was performed on female C3H/He mice aged 12 weeks in the left hind paws. Tumor cells and mononuclear cells were separated from the tumor tissue on the 12th day since inoculation of 5 x 10₆ of MM46 tumor cells which were irradiated with the dose of 2,000 rads of 3,000 rads by high energy electron beam on the fifth day. Seven days after active specific immunotherapy 1 x 10₅ or 1 x 10₆ of tumor cell were i noculated in the right hind paws of mice which received active specific immunotherapy. Anti-tumor effect was evaluated by the changes of tumor volume and survival rate. The tumor volume of the group which received active specific immunotherapy was smaller than that without active specific immunotherapy for about nine days since inoculation. Fifty-day survival rate was significantly higher in the group which received active specific immunotherapy compared with the group without immunotherapy (p < 0.01). (author)

[en] The effectiveness of active specific immunotherapy prepared from a low-dose irradiated tumor tissue has already reported. The present study was designed to investigate the effect of Mitomycin C-treated active specific immunotherapy. Twelve-week-aged female C3H/He mice transplanted with MM 46 tumors were exposed to local electron radiotherapy with a dose of 3,000 rad on the 5th day after tumor inoculation. Tumor cells prepared for active specific immunotherapy were pretreated with Mitomycin C at concentration of 20 μg/10⁷ cells in Eagle MEM Earle containing 100 IU/ml penicillin. The cell suspension was incubated at 37⁰C for 15 minutes. Mitomycin C-treated active specific immunotherapy was performed on the 12th day. Antitumor effect was evaluated by the regression of the tumor and survival curve. The remarkable regression of the tumor and significant elongation of the survival period were observed in the group which received Mitomycin C-treated active specific immunotherapy and the group which received active specific immunotherapy without the treatment of Mitomycin C. (author)