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AbstractAbstract
[en] Based on MRI diffusion's and perfusion, a new criterion for detection and the healing progress of damaged tissue is suggested. The study is based on the ratio of capillary radii in symmetrical damaged and normal tissue neighboring spaces. The apparent diffusion coefficient and cerebral blood flow were measured in the brain tissues of six male wistar rats utilizing suggested MRI measurement techniques. The apparent diffusion coefficient values of damaged and normal regions were (392±34.1) x10-6 mm2s-1 and (659±40.7)x10-6 mm2s-1, respectively. The cerebral blood flow values of damaged and normal regions were 14.5±10.13 mi/min/100 g and 125±41.03 mi/min/100 g, respectively. The geometrical parameters of the capillary for damaged and normal regions midle root/√ Λ, where midle root is the mean radius and Λ is the mean capillary segment length , were calculated to be 5.45±2.01mm0.5g-0.5 (mean±Sd) and 12.8±2.04 mm0.5g-0.5, respectively. Furthermore, based on constant Λ, the damaged, versus normal region, mean radius, was shown to follow the criterionmidle root Damaged≅0.13xmidle root Normal. A further analysis was conducted through suitable theoretical modeling and assumptions for the above-mentioned criterion. The analysis showed a distinct difference between normal and damaged tissues in various healing progress conditions. Moreover, a new image, namely, Diffusion/Flow map (DF map), which is a mere division of the ADC map to the cerebral blood flow map, was introduced and utilized to contrast between normal and damaged tissue
Primary Subject
Source
Available from Atomic Energy Organization of Iran
Record Type
Journal Article
Literature Type
Numerical Data
Journal
Scientia Iranica; ISSN 1026-3098; ; v. 12(no.1); p. 109-115
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