[en] The concept of safety culture used in nuclear forums refers to the series of actions aimed at guaranteeing that safety issues in nuclear power plants are adequately addressed. The activities to which this concept refers have been gradually extended over the years so that, today, they encompass the whole organizations structure. In other words, the safety culture implies that all positions in the organizational structure perform their tasks with a level of attention such that all their senses are focused on them. And this performance is what leads us to excellence in plant operation. In addition, the implementation of a self-assessment system in the Cofrentes Nuclear Power Plant of its activities and processes has resulted in the identification of expectations on the basis of which we can identify strengths and weaknesses, enabling us to leverage the former and correct the latter. (Author)

[en] The enforcement of quality in diagnostic radiology (Royal Decree 1976/1999 laying down the criteria for quality in diagnostic radiology and Royal Decree 815/2001 to justify the use of ionizing radiations for medical exposure, etc.) and recommendations and European regulations on the matter, is done by carrying out the optimization of the doses received, based on image quality in a continuous process of monitoring of such dose from the dose reference Values ??(VRD ) that the system has allowed to establish for each technique.

[en] We solve exactly the problem of calculating the electromagnetic fields produced by a finite wire with a constant current, by using two methods: retarded potentials and Jefimenko's formalism. One result in this particular case is that the usual Biot-Savart law of magnetostatics gives the correct magnetic field of the problem. We also show graphically the corresponding Poynting vector

[en] We show that the problem of the rocket with friction linear in the velocity can be treated by canonical methods. In order to achieve this we must abandon the restriction to natural Lagrangians of the form L = T - V, and use the method of S-equivalent Lagrangians. We also solve the problem with constant gravity. This example may be useful for the teaching of the application of canonical methods to dissipative systems, as well as to the teaching of the use of the method of S-equivalent Lagrangians

[en] The present work is a generalization of the work of Ribberfors and Reitz (2000 Eur. J. Phys. 21 151-7). These authors study a system consisting of a collar that is restricted to move in a path defined by a rod of some prescribed form which passes through the collar. We generalize the analysis of this system by means of canonical treatment. We show in this way that this excellent example can also be used in advanced courses on mechanics to show the power of the methods of analytical mechanics. We have that the present treatment of this example will be useful for advanced undergraduate and graduate students as well as for the teachers of these courses on classical mechanics. (letters and comments)

[en] We explore the consequences of a force density, - (1)/c (∂M)/∂t x E, studied by some authors, for the device designed by Lai (1980 Am. J. Phys. 48 658) to analyse which definition of electromagnetic momentum density, either Minkowski's or Abraham's, is consistent with mechanical torques that arise from the change in time of a magnetic field, which produces an induced electric field that acts on free and polarization charges. It is found that Minkowski's definition is consistent with the mechanical torques associated with free charges, while Abraham's is consistent with mechanical torques associated with both free and polarization charges. We show that with this new force density Lai's work (1980 Am. J. Phys. 48 658) can be extended to include magnetic media. The results are consistent with Abraham's definition of electromagnetic momentum density, extending in this way its usefulness to magnetic media.

[en] We clarify the contribution of Ragusa and Lazo (2004 Eur. J. Phys. 25 127-31) to the problem of covariance of electromagnetic momentum as given by Poynting's vector and the associated problem of the 4/3 in the electromagnetic mass. In particular, we note that the authors are not conscious of von Laue's theorem which makes their discussion mostly unnecessary. (letters and comments)

[en] Aurora kinase overexpression has been observed in patients with hematologic malignancies. MK-0457, a pan-aurora kinase inhibitor that also inhibits the ABL T315I mutant, was evaluated to treat patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome (Ph+) acute lymphoblastic leukemia (ALL) with the T315I mutation. Adults with Ph+ chronic phase (CP)-, accelerated phase (AP)- or blast phase (BP)-CML, or ALL and documented BCR-ABL T315I mutation were treated with a 5-day continuous infusion of MK-0457 administered every 14 days at 40 mg/m²/h, 32 mg/m²/h or 24 mg/m²/h. Fifty-two patients (CP, n=15; AP, n=14; BP, n=11; Ph+ ALL, n=12) were treated. Overall, 8% of patients achieved major cytogenetic response; 6% achieved unconfirmed complete or partial response; 39% had no response. Two patients (CP CML) achieved complete hematologic response. No patients with advanced CML or Ph+ ALL achieved major hematologic response. The most common adverse event (AE) was neutropenia (50%). The most common grade 3/4 AEs were neutropenia (46%) and febrile neutropenia (35%). MK-0457 demonstrated minimal efficacy and only at higher, intolerable doses; lower doses were tolerated and no unexpected toxicities were observed. These data will assist in the development of future aurora kinase inhibitors and in the selection of appropriate target patient populations