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[en] A method is described of NMR imaging or spectroscopy, comprising the steps of administering to a living subject a ¹⁹F labelled NMR agent, the NMR agent comprising (a) a transport polymer selected from the group consisting of dextran polymers and amino dextrans, having a molecular weight between approximately 100 d and 500 kd, and antibodies and fragments thereof, and (b) a 19F-containing sensor moiety selected from the group consisting of fluorinated alkyls, fluorinated acetates, fluoroaniline, and fluoroalkyl phosphonates, in an amount effective to provide a detectable NMR signal; and then detecting the ¹⁹F NMR signal produced

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[en] Radionuclides produced by cyclotron have played an important role in clinical nuclear medicine. Among these, ²⁰¹Tl, ¹²³I, ¹¹¹In and ⁶⁷Ga in various chemical forms have important applications in the diagnosis of cancer and heart disease using scintigraphic imaging techniques. Cardiac imaging using nuclear scintigraphy and echocardiography has been among the fastest growing diagnostic technologies in medicine during the past 15 years. Development of new tracers in conjunction with new equipment with better resolution has contributed to the better quantification and analysis of test results. The development of new biomolecules, monoclonal antibodies to myosin, platelets, fibrin and other receptor binding agents has added a new dimension to nuclear imaging studies. (orig.)

[en] Radiolabeled inhibitors of the pancreatic protease enzymes trypsin and chymotrypsin: I-125-soybean inhibitor (SBI), I-125-human antitrypsin (HAT), and ³H-diisopropylfluorophosphate (DFP) were studied in rats for their uptake in the pancreas. The protease enzyme inhibitor, SBI, was found to retain its enzymatic activity after radio-iodine labeling by iodine-monochloride method. Assay of tissues radioactivity at 5, 15, 30, 60 min and 24 hr after iv injection in rats showed pancreas:liver (P:L) ratios of < 1.4 and pancreas:blood (P:B) ratios of < 1 at all time intervals for each compound. However, ip injection of I-125 SBI showed preferential uptake in pancreas, P:L mean ratios [anti x (range)] of 6.0 (5.5 to 6.3) and P:B mean ratios of [anti x (range)] 2.60 (1.8 to 3.4), up to 60 minutes. These ratios resemble those of Se-75-selenomethionine except that kidney values are higher. Our data suggest that radiolabeled proteins can also show similar good early pancreatic uptake when given ip by escaping immediate liver metabolism. Proteins can readily be tagged with desirable gamma-emitting radionuclides (viz. I-131, I-123, Tc-99m) compared to amino acids and may potentially be suitable for imaging the pancreas. It may be important to study both iv and ip routes of administration in evaluating the specificity/affinity of potential pancreatic radiopharmaceuticals

[en] Radioiodinated phenyl fatty acids are prepared using an organothallium intermediate. Radiochemical yields of ₁₂₃I- and ₁₂₅I-phenylpentadecanoic acid are consistently high, and tissue distribution studies in rats indicate that this method of production is comparable to direct iodination. (U.K.)

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