[en] The 18 GHz PHOENIX V2 ECRIS is running since 2010 on the heavy ions low energy beam transport line (LEBT) of SPIRAL2 installed at LPSC Grenoble. PHOENIX V2 will be the starting ion source of SPIRAL 2 at GANIL. The status and future developments of this source are presented in this paper. Recent studies with Oxygen and Argon beams at 60 kV have demonstrated reliable operation at 1.3 emA of O⁶⁺ and 200 eμA of Ar¹²⁺. Metallic ion beam production has been studied with the Large Capacity Oven developed by GANIL and 20 eμA of Ni¹⁹⁺ have been obtained. In order to improve further the beam intensities for Spiral2, an economical upgrade of the source named PHOENIX V3 has been recently decided by the project management. The goal is to double the plasma chamber volume from 0.6 to 1.2 liter by increasing the chamber wall radius, keeping the whole magnetic confinement intensity unchanged. The PHOENIX V3 magnetic design will be presented along with a status of the project.This work is partially funded by the European Commission under the 7th Framework Programme Grant Agreement 283745 (CRISP).

[en] The PHOENIX ECR charge breeder characteristics (efficiency and charge breeding time) were measured at CERN-ISOLDE and LPSC, they were considered as sufficient to allow its setup on various facilities (TRIUMF-Canada/GANIL-SPIRAL2- France/SPIRAL1). The developments performed at the Argonne National Laboratory (USA) have shown that the ECR charge breeder efficiencies could be much higher than the ones obtained with PHOENIX, without major differences between the two devices. We have tried to study the possible reasons of such different results in order to improve the PHOENIX charge breeder characteristics. The transmission value of the n+ beam line has been measured to be as low as 30%. Emittances of the total beam extracted from the source and of some analyzed beams (after the magnetic spectrometer) have been measured and will be presented. Simulations have shown a too low vertical acceptance at the center of the dipole. Simulations and experimental results will be presented to show how an additional Einzel lens inserted just before the dipole have drastically improve the beam transmission. The impact of this new beam transport on efficiency results will be presented.

[en] The Grenoble Subatomic Physics and Cosmology Laboratory - LPSC aims to improve our knowledge about the most elementary particles and about the forces that govern their interactions. It helps to broaden our understanding of the universe, its structure and its evolution. The LPSC is a Mixed Teaching and Research Unit, affiliated to the National Nuclear and Particle Physics Institute (IN2P3), the National Institute of Universe Sciences (INSU) and the National Institute of Engineering Sciences and Systems (INSIS) from the National Centre for Scientific Research (CNRS), as well as to the Joseph Fourier University and the Grenoble National Polytechnique Institute. The LPSC also plays a significant role at the national level and is involved in several international scientific and technical projects. Fundamental research is the driving force of LPSC activities. Among the themes studied at the LPSC, some are focused on the greatest unsolved mysteries of the universe, e.g. the unification of forces, the origin of the mass of particles, the origin of the matter-antimatter asymmetry in the universe and the search for dark matter and energy. Research starts at the scales of the nuclei of atoms and even much smaller, where quantum and relativistic physics laws prevail. The goal here is to understand the characteristics of the most elementary building blocks of matter and their interactions, to study the limits of existence of atoms and to discover new states of nuclear matter, such as the quark-gluon plasma. Research also extends towards the infinitely large; the goal here is to understand the origin of the structures of the universe and the cosmic phenomena that take place, and to understand the characteristics of the very first stages of the universe, just after the Big Bang. The branches of physics at these two extremes are actually closely linked. Infinitely small-scale physics plays an essential role in the first moments of the universe. Particle physics and cosmology both seek answers to the existence of dark matter and dark energy in the universe. The locations of the experiments are very diverse: ground-based, underground-based or even satellite-based. LPSC also studies artificially created short-lived particles (created by accelerators which our laboratory helps to design) or cosmic particles that were produced at different epochs of the history of the universe. These activities require the development of sophisticated, state-of-the-art instrumentation. A close collaboration between physicists, engineers and technicians is required to achieve the required performance. In addition, a strong theoretical research activity supports the experiments during the preparatory stages and during the data analysis. This report presents the activities of the laboratory during the years 2006-2007: 1 - Forewords; 2 - Quarks, leptons and FUNDAMENTAL INTERACTIONS (ATLAS, DΦ, International Linear Collider (ILC) project, Ultra-cold Neutrons (UCN): nEDM and GRANIT projects; 3 - Astro-particles and Observational Cosmology (Cosmic radiation detection and phenomenology, dark matter detection, ultra-high energy cosmic rays); 4 - Hadrons and nuclei, reactor physics (nucleons and light nuclei structure, baryonic spectroscopy at GRAAL, Nuclear structure, Reactor physics); 5 - Theoretical physics (few-body quantum systems, high-energy physics); 6 - Interdisciplinary research (physics-medicine interface, hadron-therapy and CNAO, Research centre on plasmas-materials-nano-structures - CRPMN); 7 - Accelerators and ion sources; 8 - Technology valorisation and transfer; 9 - Teaching and training; 10 - Communication department; 11 - Technological developments and support to research activities: detectors and Instrumentation, Mechanics, Electronics, Data acquisition and Computers departments, General services, safety and radiation protection, Administration and financial department, human resources; 12 - Publications, PhDs, accreditations to supervise research; 13 - Staff

[en] The Grenoble Subatomic Physics and Cosmology Laboratory - LPSC aims to improve our knowledge about the most elementary particles and about the forces that govern their interactions. It helps to broaden our understanding of the universe, its structure and its evolution. The LPSC is a Mixed Teaching and Research Unit, affiliated to the National Nuclear and Particle Physics Institute (IN2P3), the National Institute of Universe Sciences (INSU) and the National Institute of Engineering Sciences and Systems (INSIS) from the National Centre for Scientific Research (CNRS), as well as to the Joseph Fourier University and the Grenoble National Polytechnique Institute. The LPSC also plays a significant role at the national level and is involved in several international scientific and technical projects. Fundamental research is the driving force of LPSC activities. Among the themes studied at the LPSC, some are focused on the greatest unsolved mysteries of the universe, e.g. the unification of forces, the origin of the mass of particles, the origin of the matter-antimatter asymmetry in the universe and the search for dark matter and energy. Research starts at the scales of the nuclei of atoms and even much smaller, where quantum and relativistic physics laws prevail. The goal here is to understand the characteristics of the most elementary building blocks of matter and their interactions, to study the limits of existence of atoms and to discover new states of nuclear matter, such as the quark-gluon plasma. Research also extends towards the infinitely large; the goal here is to understand the origin of the structures of the universe and the cosmic phenomena that take place, and to understand the characteristics of the very first stages of the universe, just after the Big Bang. The branches of physics at these two extremes are actually closely linked. Infinitely small-scale physics plays an essential role in the first moments of the universe. Particle physics and cosmology both seek answers to the existence of dark matter and dark energy in the universe. The locations of the experiments are very diverse: ground-based, underground-based or even satellite-based. LPSC also studies artificially created short-lived particles (created by accelerators which our laboratory helps to design) or cosmic particles that were produced at different epochs of the history of the universe. These activities require the development of sophisticated, state-of-the-art instrumentation. A close collaboration between physicists, engineers and technicians is required to achieve the required performance. In addition, a strong theoretical research activity supports the experiments during the preparatory stages and during the data analysis. This report presents the activities of the laboratory during the years 2008-2009: 1 - Forewords, Presentation of the laboratory; 2 - Quarks, leptons and FUNDAMENTAL INTERACTIONS (DΦ experiment at Tevatron, ATLAS experiment at LHC, International Linear Collider (ILC) project, Ultra-cold Neutrons (UCN); 3 - Astro-particles and Observational Cosmology (ultra-high energy cosmic radiation, ultra-high energy cosmic rays: Auger and CODALEMA projects, fossil radiation study with PLANCK, Large Synoptic Survey Telescope (LSST) experiment and theoretical activity, MIMAC (MIcro-tpc MAtrix of Chambers) project; 4 - Hadrons and nuclei (neutron-rich nuclei structure, nucleon structure, ALICE experiment at LHC); 5 - Reactor physics: Molten Salt Fast Reactor (MSFR), Molten Salt physico-chemistry and technologies, nuclear data, High Conversion Water Reactors (HCWR) simulation, ADS on-line reactivity monitoring validation (GUINEVERE project); 6 - Theoretical physics (nuclei, hadrons and few-body systems, lattice QCD, perturbative QCD and supersymmetry); 7 - Interdisciplinary research (hadron-therapy, Tomography, Research centre on plasmas-materials-nano-structures - CRPMN); 8 - Accelerators (SPIRAL2 Project, GENEPI-3C accelerator, 60 GHz ECR ion source prototypes, R and D activities); 9 - Technological platforms: PEREN-Chemistry, International Platform for Advanced Plasma Processing (IAP3), plasmas and Ion Sources at the electronic cyclotronic resonance (SIRCE), Nuclear Physics Platform, IN2P3-LPSC grid node; 10 - Support to research activities: Administration and financial department, Documentation and Communication department, Health and safety, radiation protection, General services, detectors and Instrumentation, Mechanics, Electronics, Data acquisition and Computers departments; 11 - Valorisation and technology transfer (low-level counting facility, accelerators and ion sources pole, Research centre on plasmas-materials-nano-structures - CRPMN, Electronics for MEMS (Micro-Electro-Mechanical Systems), management of resource booking); 12 - Teaching and training; 13 - Communication and dissemination of scientific knowledge; 14 - Seminars; 15 - Publications, PhDs, accreditations to supervise research; 16 - Staff

[en] The Grenoble Subatomic Physics and Cosmology Laboratory - LPSC aims to improve our knowledge about the most elementary particles and about the forces that govern their interactions. It helps to broaden our understanding of the universe, its structure and its evolution. The LPSC is a Mixed Teaching and Research Unit, affiliated to the National Nuclear and Particle Physics Institute (IN2P3), the National Institute of Universe Sciences (INSU) and the National Institute of Engineering Sciences and Systems (INSIS) from the National Centre for Scientific Research (CNRS), as well as to the Joseph Fourier University and the Grenoble National Polytechnique Institute. The LPSC also plays a significant role at the national level and is involved in several international scientific and technical projects. Fundamental research is the driving force of LPSC activities. Among the themes studied at the LPSC, some are focused on the greatest unsolved mysteries of the universe, e.g. the unification of forces, the origin of the mass of particles, the origin of the matter-antimatter asymmetry in the universe and the search for dark matter and energy. Research starts at the scales of the nuclei of atoms and even much smaller, where quantum and relativistic physics laws prevail. The goal here is to understand the characteristics of the most elementary building blocks of matter and their interactions, to study the limits of existence of atoms and to discover new states of nuclear matter, such as the quark-gluon plasma. Research also extends towards the infinitely large; the goal here is to understand the origin of the structures of the universe and the cosmic phenomena that take place, and to understand the characteristics of the very first stages of the universe, just after the Big Bang. The branches of physics at these two extremes are actually closely linked. Infinitely small-scale physics plays an essential role in the first moments of the universe. Particle physics and cosmology both seek answers to the existence of dark matter and dark energy in the universe. The locations of the experiments are very diverse: ground-based, underground-based or even satellite-based. LPSC also studies artificially created short-lived particles (created by accelerators which our laboratory helps to design) or cosmic particles that were produced at different epochs of the history of the universe. These activities require the development of sophisticated, state-of-the-art instrumentation. A close collaboration between physicists, engineers and technicians is required to achieve the required performance. In addition, a strong theoretical research activity supports the experiments during the preparatory stages and during the data analysis. This report presents the activities of the laboratory during the years 2010-2011: 1 - Forewords, Presentation of the laboratory; 2 - Quarks, leptons and FUNDAMENTAL INTERACTIONS (DΦ experiment at Tevatron, ATLAS experiment at LHC, International Linear Collider (ILC) project, Ultra-cold Neutrons (UCN); 3 - Astro-particles and Cosmology (ultra-high energy cosmic radiation, ultra-high energy cosmic rays, fossil radiation study with PLANCK, Large Synoptic Survey Telescope (LSST) experiment and theoretical activity, Directional detection of dark matter with MIMAC (MIcro-tpc Matrix of Chambers); 4 - Hadrons and nuclei (ALICE experiment at LHC, Study of the isomeric states of neutron-rich rubidium nuclei, Hadrons structure); 5 - Reactor physics: nuclear data, ADS subcritical reactors (GUINEVERE/FREYA project), Molten Salt Fast Reactor (MSFR) concept development, Thorium cycle with water reactors; 6 - Theory and phenomenology: perturbative QCD and accurate calculations, Beyond-the-Standard-Model, Lattice calculations, nuclei, hadrons and few-body systems; 7 - Interdisciplinary research (Research centre on plasmas-materials-nano-structures - CRPMN, Medical profiler); 8 - Accelerators and ion sources (SPIRAL2 Project, GENEPI-3C accelerator for the ADS GUINEVERE program, GENEPI-2 accelerator, 60 GHz ECR ion source prototype, Ion sources applications, Other projects and activities); 9 - Technological platforms: International Platform for Advanced Plasma Processing (IAP3), Molten Salts platform, Nuclear Physics Platform, IN2P3-LPSC grid node calculation platform; 10 - Support to research activities: Administration and financial department, Documentation and Communication department, Health and safety, radiation protection, General services, detectors and Instrumentation, Mechanics, Electronics, Data acquisition and Computers departments; 10 - Valorisation and technology transfer (low-level counting facility, MASSAR project, COMIC ion sources for FIB, COMIMAC astro-particles project, ZNeTS Network Traffic Supervisor software, Medical developments and applications, Research centre on plasmas-materials-nano-structures - CRPMN); 11 - Teaching and training; 12 - Communication and dissemination of scientific knowledge; 13 - Seminars; 14 - Publications, PhDs, accreditations to supervise research; 15 - Staff

[en] The Grenoble Subatomic Physics and Cosmology Laboratory - LPSC aims to improve our knowledge about the most elementary particles and about the forces that govern their interactions. It helps to broaden our understanding of the universe, its structure and its evolution. The LPSC is a Mixed Teaching and Research Unit, affiliated to the National Nuclear and Particle Physics Institute (IN2P3), the National Institute of Universe Sciences (INSU) and the National Institute of Engineering Sciences and Systems (INSIS) from the National Centre for Scientific Research (CNRS), as well as to the Joseph Fourier University and the Grenoble National Polytechnique Institute. The LPSC also plays a significant role at the national level and is involved in several international scientific and technical projects. Fundamental research is the driving force of LPSC activities. Among the themes studied at the LPSC, some are focused on the greatest unsolved mysteries of the universe, e.g. the unification of forces, the origin of the mass of particles, the origin of the matter-antimatter asymmetry in the universe and the search for dark matter and energy. Research starts at the scales of the nuclei of atoms and even much smaller, where quantum and relativistic physics laws prevail. The goal here is to understand the characteristics of the most elementary building blocks of matter and their interactions, to study the limits of existence of atoms and to discover new states of nuclear matter, such as the quark-gluon plasma. Research also extends towards the infinitely large; the goal here is to understand the origin of the structures of the universe and the cosmic phenomena that take place, and to understand the characteristics of the very first stages of the universe, just after the Big Bang. The branches of physics at these two extremes are actually closely linked. Infinitely small-scale physics plays an essential role in the first moments of the universe. Particle physics and cosmology both seek answers to the existence of dark matter and dark energy in the universe. The locations of the experiments are very diverse: ground-based, underground-based or even satellite-based. LPSC also studies artificially created short-lived particles (created by accelerators which our laboratory helps to design) or cosmic particles that were produced at different epochs of the history of the universe. These activities require the development of sophisticated, state-of-the-art instrumentation. A close collaboration between physicists, engineers and technicians is required to achieve the required performance. In addition, a strong theoretical research activity supports the experiments during the preparatory stages and during the data analysis. This report presents the activities of the laboratory during the years 2014-2015: 1 - Forewords, Presentation of the laboratory; 2 - Research activities: From particles to nuclei (ATLAS experiment at LHC, Future colliders, ALICE experiment at LHC, Physics of theoretical particles, 6+ isomeric states of "1"3"6","1"3"8Sn, Exploration of collective excitations with Bohr's collective algebraic model, Ultra-cold Neutrons (UCN)); 3 - Astro-particles, Cosmology and neutrinos (Pierre Auger Observatory, High energy cosmic radiation, LSST Large Synoptic Survey Telescope and theoretical cosmology, Directional detection of dark matter with MIMAC (MIcro-tpc MAtrix of Chambers), STEREO neutrino experiment, fossil radiation study with PLANCK, NIKA and NIKA2 dual band millimeter wave polarised cameras); 4 - Physics for energy and health (nuclear data, Physics of experimental reactors (FREYA (FP7) project), Molten salt reactors (MSRs) concept study, Simulation, analysis and prospective, Development of the Transparent Detector for Radiotherapy (TraDeRa), Accelerator Based - Neutron Capture Therapies (AB-NCT), MoniDiam project for the online beam-monitoring with polycrystalline diamond detectors in hadron-therapy); 5 - Accelerators and ion sources, plasmas (SPIRAL2 Project, Development of the 5.8 GHz ECR ion source, Exploitation of the GENEPI-3C accelerator 60 GHz ECR ion sources, EMILIE (Enhanced Multi-Ionization of short-Lived Isotopes at EURISOL) collaboration, Low Energy Beam Transport line (LEBT) for the MYRRHA project, Other projects and activities, Research centre on plasmas-materials-nano-structures - CRPMN); 6 - Teaching and training, Communication and dissemination of scientific knowledge; 7 - Technological and teaching platforms, valorisation and technology transfer: GENEPI2 accelerator-based neutron source, Molten salts platform, IN2P3-LPSC grid node calculation platform, International Platform for Advanced Plasma Processing (IAP3), Low-level radioactivity measurement facility, Charge breeder of the SPES project (LNL, Legnaro), CMCF project, Medical developments and applications, MASSAR project, MIMAC-FastN valorisation project for MIMAC (MIcro-tpc MAtrix of Chambers), Polygon Physics start-up creation for the development of a high efficiency miniaturized 2.45 GHz Electron Cyclotron Resonance Ion Source; 8 - Support to research activities: Administrative and financial department, Communication and library department, detectors and Instrumentation, Mechanics, Electronics and Computers departments, Health and safety, radiation protection, Heritage and infrastructures

[en] The preferred hypothesis for the dissemination patterns of Hodgkin lymphoma (HL) is the contiguity hypothesis. However, this hypothesis is based on studies performed before the advent of [${}^{18}$F]-FDG PET/CT which is now the established reference for HL staging. This study aims to extract the dissemination patterns of HL using [${}^{18}$F]-FDG PET/CT and a probability network model. We retrospectively analyzed [${}^{18}$F]-FDG PET/CT performed for initial staging of patients with classical HL. The HL involvement status (presence of absence) was reported for 19 supra- and infra-diaphragmatic lymph node regions and 4 extranodal regions (lung, spleen, liver, and osteo- medullary). The analysis of HL dissemination was carried out using HL involvement status for all regions through 3 distinct methods: comparison of nearby lymph node regions, correlation assessment between all regions and relationship strength between all regions using Ising network model. A total of 196 patients were included. Our results showed strong relationships between nearby involved lymph node regions (for example between the left pelvic and the abdominal lymph node regions (relationship strength = 0.980)) and between more distant regions (for example between right and left axillary lymph node regions (strength = 0.714)). Furthermore, involvement of the infra-diaphragmatic lymph node regions was significantly correlated with Ann Arbor stage IV (phi = 0.56, p < 0.001). This study confirms the hypothesis of lymphatic dissemination of HL in a contiguous mode, with additional links between more distant regions. These predictable dissemination patterns could be useful for the initial staging assessment of patients with HL using [${}^{18}$F]-FDG PET/CT.

[en] We report here on the last progresses made with the PHOENIX electron cyclotron resonance charge breeder test bench at ISOLDE. Recently, an experiment was performed to test the trapping of ⁶¹Fe daughter nuclides from the decay of ⁶¹Mn nuclides. Preliminary results are given

[en] The aim of this study was to assess the usefulness of positron emission tomography/computed tomography in staging, prognosis evaluation and restaging of patients with follicular lymphoma. A retrospective study was performed on 45 patients with untreated biopsy-proven follicular lymphoma who underwent ¹⁸F-fluorodeoxyglucose PET/CT (FDG PET/CT) and CT before and after chemoimmunotherapy induction treatment (rituximab combined with cyclophosphamide, doxorubicin, vincristine and prednisone). PET/CT detected more nodal (+51%) and extranodal (+89%) lesions than CT. PET/CT modified Ann Arbor staging in eight patients (18%). Five patients (11%) initially considered as being early stage (I/II) were eventually treated as advanced stage (III/IV). In this study, an initial PET/CT prognostic score was significantly more accurate than the Follicular Lymphoma International Prognostic Index score in identifying patients with poor prognosis (i.e. patients with incomplete therapeutic response or early relapse). The accuracy of PET/CT for therapeutic response assessment was higher than that of CT (0.97 vs 0.64), especially due to its ability to identify inactive residual masses. In addition, post-treatment PET/CT was able to predict patients' outcomes. The median progression-free survival was 48 months in the PET/CT-negative group as compared with 17.2 months for the group with residual uptake (p < 10^-4). FDG PET/CT is useful for staging and assessing the prognosis and therapeutic response of patients with follicular lymphoma. (orig.)

[en] The Accelerators meeting is organised every two years by the Accelerators division of the French Society of Physics (SFP). It brings together about 50 participants during a one-day meeting. The morning sessions are devoted to scientific presentations while the afternoon is dedicated to technical visits of facilities. This document brings together the available presentations (slides): 1 - Presentation of the Laboratory of subatomic physics and cosmology - LPSC-Grenoble (Lucotte, Arnaud; Lamy, Thierry); 2 - Presentation of the Accelerators division of the French Society of Physics (Fontaine, Alain; Revol, Jean-Luc); 3 - Presentation of Grenoble's master diplomas in Accelerator physics (Nadolski, Laurent S.); 4 - Presentation of Paris' master diplomas in big instruments (Kazamias, Sophie); 5 - Particle accelerators and European Union's projects (Vretenar, Maurizio); 6 - French research infrastructures (Ferrando, Philippe); 7 - Coordination of accelerators activity in France (Laune, Bernard; Vedrine, Pierre)