[en] The flotation of hemimorphite using the S(II)–Pb(II)–xanthate process, which includes sulfidization with sodium sulfide, activation by lead cations, and subsequent flotation with xanthate, was investigated. The flotation results indicated that hemimorphite floats when the S(II)–Pb(II)–xanthate process is used; a maximum recovery of approximately 90% was obtained. Zeta-potential, contact-angle, scanning electron microscopy–energy-dispersive spectrometry (SEM–EDS), and diffuse-reflectance infrared Fourier transform spectroscopy (DRIFTS) measurements were used to characterize the activation products on the hemimorphite surface and their subsequent interaction with sodium butyl xanthate (SBX). The results showed that a ZnS coating formed on the hemimorphite surface after the sample was conditioned in an Na2S solution. However, the formation of a ZnS coating on the hemimorphite surface did not improve hemimorphite flotation. With the subsequent addition of lead cations, PbS species formed on the mineral surface. The formation of the PbS species on the surface of hemimorphite significantly increased the adsorption capacity of SBX, forming lead xanthate (referred to as chemical adsorption) and leading to a substantial improvement in hemimorphite flotation. Our results indicate that the addition of lead cations is a critical step in the successful flotation of hemimorphite using the sulfidization–lead ion activation–xanthate process.