[en] During the past several years, the Chinese nuclear industry has seen rapid development and more applications of nuclear simulation technology. This article summarizes the real time simulation technology used for nuclear engineering in Research Institute of Nuclear Research Institute (RINPO). RINPO has developed its latest simulation technology in two key aspects, one is the general Linux-based simulation platform RINSIMTM, which consists of real time development and operating environment, the instructor station, the operator stations and all graphical object-oriented modeling tools. The other is the modeling technology, including five-equation thermalhydraulic code, real time RELAP5 simulation code, 3D reactor physics code, and DCS Emulation solution. The advanced simulation technology makes the simulator development less labor intensive, better maintainability, and high fidelity assured. (authors)

[en] In the present study, we introduced the nitrogenated heterocycles and fluorine atoms into the 2,5′-dibromo-4,5,2′-trihydroxyl diphenylmethanone (LM49), a bromophenol analog previously reported for its strong antioxidant ability involving in the Keap1–Nrf2 pathway. Twenty-seven fluorophenols 6a–6g, 8a–8k, 10a–10g, and 12a–12b were prepared, evaluated for their antioxidant activity in EA.hy926 cells, and investigated their interacted approach and probable mode of action with key protein Keap1 by molecular docking. Fluorophenols 6f, 8d, 8f, 8h, and 8i with EC₅₀ values ranging from 0.82 to 6.71 µM were found to be more active compared with the standard control quercetin (EC₅₀ = 18 µM). Among them, compound 8h with an EC₅₀ value of 0.82 µM showed the identical activity to lead compound LM49 (EC₅₀ = 0.7 µM). Moreover, the preferable water solubility and forming salt possibility of 8h contribute to its druggability. Further molecular docking of the optimal compound 8h with key protein Keap1 indicated that 8h stably bonded to the receptor protein by the formation of hydrogen bonds, the conjugated six-membered ring was close to the key residue Arg-415 attached to the Nrf2 on Keap1-Kelch, affecting its properties, and the change leaded to the dissociation of Nrf2 from the junction with Keap1-Kelch into the nucleus exerting its antioxidant protective effect. This study introduced a class of fluorophenols containing nitrogenated heterocycles for the development of novel Keap1-Nrf2 protein–protein interaction (PPI) inhibitors. Keap1-Kelch is suggested the most potential target protein for such class of halophenols.

[en] n-ZnO/p-GaN heterojunction light-emitting diodes with and without a Ga₂O₃ interlayer are fabricated. The electroluminescence (EL) spectrum of the n-ZnO/p-GaN displays a single blue emission at 430 nm originating from GaN, while the n-ZnO/Ga₂O₃/p-GaN exhibits a broad emission peak from ultraviolet to visible. The broadened EL spectra of n-ZnO/Ga₂O₃/p-GaN are probably ascribed to the radiative recombination in both the p-GaN and n-ZnO, due to the larger electron barrier (ΔE_C = 1.85 eV) at n-ZnO/Ga₂O₃ interface and the much smaller hole barrier (ΔE_V = 0.20 eV) at Ga₂O₃/p-GaN interface. (interdisciplinary physics and related areas of science and technology)