[en] The electron beam welding (EBW) of 304 stainless steel to QCr0.8 copper alloy with or without copper filler wire was studied in detail. The temperature fields and magnitude and distribution of stress fields in the joints during the welding process were numerically simulated using finite element method. The temperature cycles and residual stresses were also experimentally measured by thermometric and hole-drilling methods, respectively. The accuracy of the modeling procedure was verified by the good agreement between the calculated results and experimental data. The temperature distribution in the joint was found to be asymmetric along the center of weld. In particular, the temperature in the copper alloy plate is much higher than that in the 304 SS plate owing to the great difference in thermal conductivity between the two materials. The peak three-dimensional residual stresses all appeared at the interface between the copper and steel in the two different joints. Furthermore, the weld was subjected to tensile stress. The longitudinal residual stress, generally the most harmful to the integrity of the structure among the stress components in EBW with filler wire (EBFW), was 53 MPa lower than that of autogenous EBW (AEBW), and the through-thickness residual stress was 12 MPa lower. The transverse residual stress of EBFW was 44 MPa higher than that of AEBW. However, analysis of the von Mises stress showed that the EBFW process effectively reduced the extent of the high residual stress region in the weld location and the magnitude of the residual stresses in the copper side compared with those of the AEBW joint. - Highlights: • Copper and steel was welded by electron beam welding with copper filler wire. • The copper wire fed into gap can reduce the peak value of residual stress. • The peak value of longitudinal stress can be reduced 53 MPa by the filler wire. • The range of nov Mises stress in the weld could be reduced by the wire

[en] Highlights: • ¹²⁵I-Herceptin has a high affinity for HER2 in MC38 colon cancer cells. • SPECT imaging of HER2 in colon cancer using ¹²⁵I-Herceptin is feasibility. • An effective, non-invasive and less costly in vivo detection method of HER2. An accurate assessment of HER2 status in patients with colorectal cancer is very important, because only the patients overexpressing HER2 can benefit most from the anti-HER2 targeted therapy. In this study, we investigated the feasibility of detecting HER2 expression in colon cancer by SPECT imaging using ¹²⁵I-Herceptin, which showed high labeling rate, good in vitro stability and high binding specificity for HER2. HER2-positive mouse colon adenocarcinoma cell line (MC 38) was chosen as the colon caner cell model, and used for the establishment of colon cancer-bearing nude mice model. SPECT/CT imaging suggested that the tumors can be visualized at 12 h after the injection of ¹²⁵I-Herceptin, and the uptake of tracer in tumors reached the peak at 24 h after injection, and can be attenuated significantly by pretreatment with an excess of nonlabeled Herceptin. These results indicates that ¹²⁵I-Herceptin can be considered as an effective SPECT probe for the non-invasive detection of HER2 expression in colon cancer.

[en] Single slepton production in association with a top quark at the CERN Large Hadron Collider (LHC) is one of the important processes in probing the R-parity violation couplings. We calculate the QCD next-to-leading order (NLO) corrections to the pp→tl^-(anti tl⁺) + X process at the LHC and discuss the impacts of the QCD corrections on kinematic distributions. We investigate the dependence of the leading order (LO) and the NLO QCD corrected integrated cross section on the factorization/renormalization energy scale, slepton, stop-quark and gluino masses. We find that the uncertainty of the LO cross section due to the energy scale is obviously improved by the NLO QCD corrections, and the exclusive jet event selection scheme keeps the convergence of the perturbative series better than the inclusive scheme. The results show that the polarization asymmetry of the top-quark will be reduced by the NLO QCD corrections, and the QCD corrections generally increase with the increment of the t₁ or g mass value. (orig.)

[en] High-quality type-Ma gem diamond crystals are successfully synthesized in a Ni₇₀Mn₂₅ C0₅-C system by temperature gradient method (TGM) at about 5.5 GPa and 1560 K. Al and Ti/Cu are used as nitrogen getters respectively. While nitrogen getter Al or Ti/Cu is added into the synthesis system, some inclusions and caves tend to be introduced into the crystals. When Al is added into the solvent alloy, we would hardly gain high-quality type-IIa diamond crystals with nitrogen concentration N_c < 1 ppm because of the reversible reaction of Al and N at high pressure and high temperature (HPHT). However, when Ti/Cu is added into the solvent alloy, high-quality type-IIa diamond crystals with N_c < 1 ppm can be grown by decreasing the growth rate of diamonds

[en] The oscillatory motions of shocks in highly underexpanded jets with nozzle pressure ratios of 5.60, 7.47, 9.34, and 11.21 are quantitatively studied by using large eddy simulation. Two types of shock oscillations are observed: one is the Mach disk oscillation in the streamwise direction and the other is the shock oscillation in the radial direction. It is found that the Mach disk moves quickly in the middle of the oscillatory region but slowly at the top or bottom boundaries. The oscillation cycles of Mach disk are the same for different cases, and are all dominated by an axisymmetric mode of 5.298 kHz. For the oscillation in the radial direction, the shocks oscillate more toward the jet centerline but less in the jet shear layer, and the oscillation magnitude is an increasing function of screech amplitude. The cycles of the radial shock oscillation switch randomly between the two screech frequencies for the first two cases. However, the oscillation periodicity is more complex for the jets with high nozzle pressure ratios of 9.34 and 11.21 than for the jets with the low nozzle pressure ratios of 5.6 and 7.47. In addition, the shock oscillation characteristics are also captured by coarse mesh and Smagorinsky model, but the coarse mesh tends to predict a slower and weaker shock oscillation. (paper)