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AbstractAbstract
[en] The review article introduce molecular imaging equipment small animal PET and PET-CT's philosophy and technique feature, small animal PET and PET-CT apply many new techniques and images resolution has obviously raising, as same time, small animal PET and small animal CT may come true image fusion, small animal PET and PET-CT permit us to engage molecular level imaging in vivo without invading, so small animal PET and PET-CT are good tool in medical molecular imaging. (authors)
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21 refs.
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Journal Article
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International Journal of Radiation Medicine and Nuclear Medicine; ISSN 1673-4114; ; v. 32(1); p. 1-4
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AbstractAbstract
[en] Function and molecular lmaging represent medical imaging' s direction. The review article introduce function and molecular's concept and category and its characteristic. Comparing with traditionary classics radiology, function and molecular imaging have many features, such as micro-mount and specificity and quantitative. There are many technology about function and molecular imaging. Function and molecular imaging is important ingredient of modern medical and play a considerable role. (authors)
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16 refs.
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Journal Article
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International Journal of Radiation Medicine and Nuclear Medicine; ISSN 1673-4114; ; v. 31(4); p. 193-196
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AbstractAbstract
[en] Objective: To investigate the effect of Gefitinib on radiosensitivity of human lung adenocarcinoma xenograft in nude mouse. Methods: Human lung adenocarcinoma cell line A549 was used to establish nude mouse xenograft tumor model. The mice were derided into 4 groups: control, irradiation alone, Gefinitib alone and radiation combined with Genifitib. Radiation schedule was 3 fractions of 5 Gy, once daily. Gefitinib was daily administered by gavage at 100 mg/(kg·day-1) for 14 days. In the combination group, radiotherapy was performed 2 hours after Gefitinib administration. Tumor diameter was measured every other day. Percentage of tumor growth inhibition, growth delay time and regrowth delay time were evaluated. Results: For A549 xenografts in radiation alone, gefitinib alone and combination therapy groups, the percentage of tumor growth inhibition was 22.7%, 12.4% and 38.2%, respectively (F=25.75, P=0.000). Tumor growth delay time was 6.0, 7.8 and 21.6 days, respectively (F=70.49, P=0.000). Tumor regrowth delay time in combination therapy and irradiation alone groups was 23.4 and 10.2 days. (F=174.24, P= 0.000). Sensitizing enhancement ratio of combination group was 1.5 in growth and 1.7 in regrowth. Conclusions: Anti-EGFR therapy enhances the radiosensitivity of human lung adenocarcinoma xenograft in nude mouse. (authors)
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2 figs., 15 refs.
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Journal Article
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Chinese Journal of Radiation Oncology; ISSN 1004-4221; ; v. 17(6); p. 473-475
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AbstractAbstract
[en] Objective: To improve the diagnostic accuracy of peripheral pulmonary masses before operation. Methods: 55 cases of peripheral lung mass with percutaneous puncture biopsy under CT guidance were compared with the postoperative pathology. Results: 44 out of 55 caes confirmed by operation were lung cancer. 40 cases showed consistent CT findings with pathology reaching accurate rate to 90.9% (40/44). 5 cases were tuberculous granuloma with accurate rate of 80% (4/5). 6 cases were inflammatory pseudotumor (with 2 cases of cryptococcal granuloma) showing accurate rate of 33.3% (2/6). Altogether 55 cases of peripheral lung masses were diagnosed correctly by CT with accurate rate of 83.6% (46/55). Conclusions: Percutaneous puncture biopsy under CT guidance for peripheral lung lesions is safe and reliable especially for planning the management. (authors)
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2 refs.
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Journal Article
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Journal of Interventional Radiology; ISSN 1008-794X; ; v. 13(6); p. 544-545
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Aihemaiti, Aikelaimu; Jiang, Jianguo; Li, De’an; Li, Tianran; Zhang, Wenjie; Ding, Xutong, E-mail: jianguoj@tsinghua.edu.cn2017
AbstractAbstract
[en] Vanadium (V) has been extensively mined in China and caused soil pollution in mining area. It has toxic effects on plants, animals and humans, posing potential health risks to communities that farm and graze cattle adjacent to the mining area. To evaluate in situ phytoremediation potentials of native plants, V, chromium, copper and zinc concentrations in roots and shoots were measured and the bioaccumulation (BAF) and translocation (TF) efficiencies were calculated. The results showed that Setaria viridis accumulated greater than 1000 mg kg−1 V in its shoots and exhibited TF > 1 for V, Cr, Zn and BAF > 1 for Cu. The V accumulation amount in the roots of Kochia scoparia also surpassed 1000 mg kg−1 and showed TF > 1 for Zn. Chenopodium album had BAF > 1 for V and Zn and Daucus carota showed TF > 1 for Cu. Eleusine indica presented strong tolerance and high metal accumulations. S. viridis is practical for in situ phytoextractions of V, Cr and Zn and phytostabilisation of Cu in V mining area. Other species had low potential use as phytoremediation plant at multi-metal polluted sites, but showed relatively strong resistance to V, Cr, Cu and Zn toxicity, can be used to vegetate the contaminated soils and stabilise toxic metals in V mining area.
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Source
Copyright (c) 2017 Springer-Verlag GmbH Germany, part of Springer Nature; Article Copyright (c) 2017 Springer-Verlag GmbH Germany; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
Journal
Environmental Science and Pollution Research International; ISSN 0944-1344; ; CODEN ESPLEC; v. 24(34); p. 26839-26850
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AbstractAbstract
[en] Objective: To evaluate the value of the 18F-fluorodenxyglucose (FDG) PET/CT in malignant tumors after gamma knife treatment. Methods: Eighteen patients with malignant tumors after gamma knife treatment were examined by PET/CT. The imaging manifestation of PET and CT was analysed. And the pre- and post-treatment changes of PET and CT were compared. Results: The effective changes in CT after therapy: shrinkage, fibrosis of the focal lesions, low density liquefied central necrosis in large lesions with patchy calcification. The result evaluated by CT analysis: complete remission (CR) 3 cases (16.7%), partial remission (PR) 10 cases (55.6%), no change (NC) 2 cases (11.1%), progress disease (PD) 3 cases (16.7%); CR + PR 72.2%. The effective changes of 34 lesions in PET: less concentrated, vague, unclear border, uneven hot areas with defect in necrotic areas. The result evaluated by PET: CR 4 cases (22.2%), PR 8 cases (44.4%), NC 1 case (5.6%), PD 5 cases (27.8%), CR + PR 66.7%. Standardized uptake value (SUV) was changed in all 34 lesions after treatment. There were 29/34 lesions decreased and 5 lesions increased. The change of ratio of SUV was greater than 50% in 15 lesions. The SUV in pre- and post-treatment group was 6.33 ± 2.62 and 3.88 ± 1.82, respectively with statistical difference between them (t=5.580, P<0.001). Conclusions: PET/CT has important value in the evaluation of local control of tumor growth after the gamma knife treatment in malignant tumors. The detection of residual and recurrent tumors in PET is apparently better than CT. (authors)
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7 refs.
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Journal Article
Journal
Chinese Journal of Nuclear Medicine; ISSN 0253-9780; ; v. 25(6); p. 355-357
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ANTIMETABOLITES, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, DISEASES, DRUGS, ELECTROMAGNETIC RADIATION, EMISSION COMPUTED TOMOGRAPHY, FLUORINE ISOTOPES, HOURS LIVING RADIOISOTOPES, IONIZING RADIATIONS, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, LIGHT NUCLEI, MATERIALS, MEDICINE, NANOSECONDS LIVING RADIOISOTOPES, NEOPLASMS, NUCLEAR MEDICINE, NUCLEI, ODD-ODD NUCLEI, PATHOLOGICAL CHANGES, RADIATIONS, RADIOACTIVE MATERIALS, RADIOISOTOPES, RADIOLOGY, THERAPY, TOMOGRAPHY
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AbstractAbstract
[en] Objective: To evaluate whether 18F-fluorothymidine (FLT) can be used to monitor early response to irradiation in colorectal cancer (CRC). Methods: SW480 cells were cultured and irradiated with 0, 10, and 20 Gy. Twenty-four hours later, morphological changes, apoptosis, necrosis, proliferation, and cell cycle phases were observed. Uptake of 18F-FLT was measured in these tumors in vitro from 24 h to 72 h after irradiation. The one-way analysis of variance was used to analyze the data. Results: Apoptotic and necrotic cells were detected 24 h after radiotherapy. SW480 cells proliferation was significantly delayed after irradiation in 3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenylte-trazolium bromide (MTT) assay. Cell cycle analysis showed that SW480 cells had a decreased fraction of cells in S phase (from 33.23% to 9.24%, then to 5.43%) and an arrested fraction in G0-G1. After SW480 cells were cultured for 60 min, the uptake of 18F-FLT was (5.21±1.60)%; and 24 h after irradiation of 10 Gy, the uptake decreased significantly to (4.27±0.48)% (F=8.253, P=0.009). And 72 h after irradiation, the uptake further decreased significantly to (3.39±0.59)% (F=36.715, P<0.001). In tumor tissue, the uptake of 18F-FLT reduced significantly 72 h after radiotherapy (10 Gy: F=12.388, P=0.007; 20 Gy: F=16.744, P=0.004) and the attenuation degree increased with the radiation dose. Conclusion: The uptake of 18F-FLT in SW480 cells or in CRC could reflect the changes of SW480 cells in proliferation, cell cycle re-distribution, cell apoptosis and necrosis. The results suggest that 18F-FLT may used for monitoring early response to irradiation of CRC. (authors)
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2 figs., 1 tabs., 13 refs.
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Journal Article
Journal
Chinese Journal of Nuclear Medicine; ISSN 0253-9780; ; v. 30(3); p. 147-150
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ANIMAL CELLS, AZINES, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM, DISEASES, DOSES, DRUGS, EMISSION COMPUTED TOMOGRAPHY, FLUORINE ISOTOPES, GASTROINTESTINAL TRACT, HETEROCYCLIC COMPOUNDS, HOURS LIVING RADIOISOTOPES, INTESTINES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, LIGHT NUCLEI, MATERIALS, MEDICINE, NANOSECONDS LIVING RADIOISOTOPES, NUCLEAR MEDICINE, NUCLEI, NUCLEOSIDES, NUCLEOTIDES, ODD-ODD NUCLEI, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANS, POPULATIONS, PYRIMIDINES, RADIOACTIVE MATERIALS, RADIOISOTOPES, RADIOLOGY, RIBOSIDES, THERAPY, TOMOGRAPHY
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AbstractAbstract
[en] Objective: To explore the artifact and infrequent physiological uptake in PET/CT with its imaging and formation features. Methods: The data of PET/CT imaging were retrospectively analyzed and classified based on their cause. Besides, the infrequent physiological uptakes were also analyzed. Results: Artifacts could be classified into natural and technological causes. In natural causes, respiratory movement and high-density matters artifacts were frequently found, whereas in technological cause, the truncation, radioactive leakage and pollution commonly appeared. Infrequent physiological uptakes included uterine endometrium, breast and fat uptakes. Conclusions: The imaging features of artifact in PET can be divided into 'hot' or 'cold' area while infrequent physiological uptakes mainly are 'hot' area. Among the cause of artifact formation, CT-based attenuation corrected physical factor is the commonest. The infrequent physiological uptake somewhat relates to technological error. (authors)
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6 figs., 12 refs.
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Journal Article
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Chinese Journal of Nuclear Medicine; ISSN 0253-9780; ; v. 26(5); p. 295-298
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ANTIMETABOLITES, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, COMPUTERIZED TOMOGRAPHY, CONTROL, DIAGNOSTIC TECHNIQUES, DRUGS, FEMALE GENITALS, FLUORINE ISOTOPES, GLANDS, HOURS LIVING RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, LIGHT NUCLEI, MATERIALS, NANOSECONDS LIVING RADIOISOTOPES, NUCLEI, ODD-ODD NUCLEI, ORGANS, PHYSICAL PROPERTIES, RADIOACTIVE MATERIALS, RADIOISOTOPES, TOMOGRAPHY
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AbstractAbstract
[en] Objective: To evaluate the predictive value of 18F-fluorodeoxyglucose (FDG) and 18F-fluorothymidine (FLT) PET in monitoring the metastatic potential of human colorectal cancer (CRC). Methods: Human CRC cell lines SW480 and SW620 were cultured and implanted into nude mice to create CRC models. Tumor growth, metastatic status and survival were assessed in CRC bearing mice. Uptake of 18F-FDG and 18F-FLT in SW480 and SW620 cells was detected In vitro at 0, 30, 60, 90, 120 min after incubation. PET images of both tracers were acquired for SW480 and SW620 tumor-bearing mice using the small animal PET at 60 min after tracer injection. Region of interest (ROI) was drawn using Image J software on reconstructed PET images. Immunocytochemistry and Western blot analysis of the tumor tissue were performed. The correlation between tracer uptake and tumor marker expression was evaluated using linear regression. Results: Compared with SW620 tumor-bearing mice, SW480 induced tumor grew much faster (t = - 3.332, P = 0.004), the tumor-bearing mice had more serious dyscrasias (t = 2.240, P = 0.038 ), shorter survival and higher metastatic rate. In vitro study, the uptake of both 18F-FDG and 18F-FLT in SW620 cells was lower than that in SW480 cells. 18F-FLT uptake was higher than 18F-FDG uptake in both SW480 and SW620 cells. After incubation for 60 min,the uptake of 18F-FDG in SW480 and SW620 cells was (1.76 ± 0.87)% and ( 1.14 ± 0.38 )%, respectively (t = -2.507, P = 0.021); while the uptake of 18F-FLT in SW480 and SW620 cells was (5.21 ± 1.60)% and (2.90 ± 1.82)%, respectively (t =3.497, P =0.002). In micro-PET study, the 18F-FDG radioactivity ratio of tumor to non-tumor (T/NT) in SW480 and SW620 tumors was 2.69 ± 0.98 and 3.09 ± 1.26 respectively (t =0.657, P =0.524); while T/NT of 18F-FLT in SW480 and SW620 tumors was 3.65 ±0.51 and 2.22 ±0.42 (t =6.491, P <0.001), respectively. In immunocytochemistry and western blot assay, heat shock protein(HSP) 27, Integrin β3, vascular endothelial growth factor receptor 2 (VEGFR2) and Ki67 were all over expressed in two kinds of tumor cells with different intensities. HSP27 and Integrin β3 expression was higher in SW480 cells than that in SW620 cells. While VEGFR and Ki67 expression was lower in SW480 cells than that in SW620 cells. The uptake of 18F-FLT closely correlated with the expression of HSP27 (r =0.924, P =0.004) and Integrin β3 (r=0.813, P =0.025). 18F-FDG uptake inversely correlated with the survival of tumor-bearing mice (r =0.500, P=0.017). Conclusions: The uptake of 18F-FDG and 18F-FLT may reflect different biological characteristics of CRC. High 18F-FLT uptake in CRC on PET scan may predict high metastatic tendency. (authors)
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5 figs., 16 refs.
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Journal Article
Journal
Chinese Journal of Nuclear Medicine; ISSN 0253-9780; ; v. 30(4); p. 226-231
Country of publication
ANIMAL CELLS, ANIMALS, ANTIMETABOLITES, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM, DISEASES, DRUGS, EMISSION COMPUTED TOMOGRAPHY, FLUORINE ISOTOPES, GASTROINTESTINAL TRACT, HOURS LIVING RADIOISOTOPES, INTAKE, INTESTINES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, LIGHT NUCLEI, MAMMALS, MATERIALS, MEMBRANE PROTEINS, MITOGENS, NANOSECONDS LIVING RADIOISOTOPES, NUCLEI, ODD-ODD NUCLEI, ORGANIC COMPOUNDS, ORGANS, PROTEINS, RADIOACTIVE MATERIALS, RADIOISOTOPES, RODENTS, TOMOGRAPHY, VERTEBRATES
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Wu, Kongyou; Pei, Yangwen; Li, Tianran; Wang, Xulong; Liu, Yin; Liu, Bo; Ma, Chao; Hong, Mei, E-mail: wukongyou@163.com, E-mail: peiyangwen@upc.edu.cn2018
AbstractAbstract
[en] The Daerbute fault zone, located in the northwestern margin of the Junggar basin, in the Central Asian Orogenic Belt, is a regional strike-slip fault with a length of ~ 400 km. The NE-SW trending Daerbute fault zone presents a distinct linear trend in plain view, cutting through both the Zair Mountain and the Hala’alate Mountain. Because of the intense contraction and shearing, the rocks within the fault zone experienced high degree of cataclasis, schistosity, and mylonization, resulting in rocks that are easily eroded to form a valley with a width of 300–500 m and a depth of 50–100 m after weathering and erosion. The well-exposed outcrops along the Daerbute fault zone present sub-horizontal striations and sub-vertical fault steps, indicating sub-horizontal shearing along the observed fault planes. Flower structures and horizontal drag folds are also observed in both the well-exposed outcrops and high-resolution satellite images. The distribution of accommodating strike-slip splay faults, e.g., the 973-pluton fault and the Great Jurassic Trough fault, are in accordance with the Riedel model of simple shear. The seismic and time-frequency electromagnetic (TFEM) sections also demonstrate the typical strike-slip characteristics of the Daerbute fault zone. Based on detailed field observations of well-exposed outcrops and seismic sections, the Daerbute fault can be subdivided into two segments: the western segment presents multiple fault cores and damage zones, whereas the eastern segment only presents a single fault core, in which the rocks experienced a higher degree of rock cataclasis, schistosity, and mylonization. In the central overlapping portion between the two segments, the sediments within the fault zone are primarily reddish sandstones, conglomerates, and some mudstones, of which the palynological tests suggest middle Permian as the timing of deposition. The deformation timing of the Daerbute fault was estimated by integrating the depocenters’ basinward migration and initiation of the splay faults (e.g., the Great Jurassic Trough fault and the 973-pluton fault). These results indicate that there were probably two periods of faulting deformation for the Daerbute fault. By integrating our study with previous studies, we speculate that the Daerbute fault experienced a two-phase strike-slip faulting deformation, commencing with the initial dextral strike-slip faulting in mid-late Permian, and then being inversed to sinistral strike-slip faulting since the Triassic. The results of this study can provide useful insights for the regional tectonics and local hydrocarbon exploration.
Primary Subject
Source
Copyright (c) 2018 Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature; Country of input: International Atomic Energy Agency (IAEA)
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Journal Article
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Frontiers of Earth Science (Online); ISSN 2095-0209; ; v. 12(3); p. 555-568
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