[en] This study aimed to investigate the relationship between the artery diameter ratio (ADR) after recanalization and clinical outcomes. Patients with middle cerebral artery occlusion confirmed by DSA from 1 January 2018, to 31 December 2019, were retrospectively analyzed. All patients confirmed TICI grade 2b or 3. The ADR was calculated as M2 segment diameter/M1 segment diameter. Multivariate regression analysis was used to describe clinical outcomes of two groups (ADR < 0.6 and $\ge <!--\; ???\; -->$ 0.6). ROC curves were used to compare different models and find the best cutoff. A total of 143 patients were included in the study, including 77 males and 66 females, with an average age of 67.79 $\pm <!--\; ??\; -->$ 12 years. The NIHSS at discharge was significantly higher in the ADR < 0.6 group than another group (mean, 16.37 vs. 6.19, P < 0.001). At 90 days, the cases of functional independence was significantly less in the ADR < 0.6 group (20.97% vs. 83.95%, OR 0.05, 95% CI 0.02-0.12, P < 0.001). The ADR < 0.6 group had a higher incidence of cerebral edema (P = 0.027) and sICH (P = 0.038). The ADR had the strongest power to distinguish mRS > 2 (AUC = 0.851) and DC (AUC = 0.805), and the best cutoff value are 0.6 (specificity 85.19%, sensitivity 75.81%) and 0.58 (specificity 65.96%, sensitivity 100%), respectively. The low ADR is associated with poor outcomes. The decrease in ADR may be an indirect manifestation of the loss of cerebrovascular autoregulation.

[en] Objective: To determine the characteristics and trends of radiological research by analyzing the original articles published in Chinese Journal of Radiology between 2001 and 2010. Methods: All 2378 original articles published in Chinese Journal of Radiology between 2001 and 2010 were evaluated. The following information was obtained from each article: radiologic subspecialty, imaging technique used, type of research, sample size, study design, statistical analysis, study outcome, declared funding, number of authors, geographic information and affiliation of the first author. In addition, all the variables presented were examined to show the trend over time. Results: The most common subspecialty of study was neuroradiology (403, 16.9%), followed by vascular/interventional (369, 15.5%) and abdominal radiology (331, 13.9%). 834 (35.1%) original articles used magnetic resonance (MR) imaging and 678 (28.5%) used computed tomography (CT). 2034 (85.5%) were clinical research articles. Eight hundred and nineteen (34.4%) researches had sample size of between 20 and 50, 1838 (77.3%) were retrospective, 1309 (55%) performed statistical analysis, and 2337 (98.3%) showed positive study outcome. Most of researches (1744, 77.3%) were not funded, 1529 (64.3%) had four to seven authors, and 2283 (96%) were written by the primary author who was from a department of radiology or radiology-related specialties. The top 3 cities where most papers were originated were Beijing (663, 27.9%), Guangzhou (349, 14.7%) and Shanghai (281, 11.8%). Breast subspecialty, MR imaging, basic research, sample size of more than 50, papers with more than seven authors, and first author from Jiangsu, Fujian and Xinjiang provinces showed a significantly positive trend with time. On the other hand, vascular interventional subspecialty, papers without statistical analysis or with less than 4 authors and papers from Shanxi province had a significantly negative trend. Conclusion: The bibliometric analysis of the articles published in Chinese Journal of Radiology between 2001 and 2010 revealed characteristics and trends of the current radiology research, which may provide useful information to researchers and editorial staff in radiology. (authors)

[en] Sex differences in Alzheimer's disease (AD) progression provide clues to pathogenesis and better patient management. We examined sex differences in emotional memory among AD patients, amnestic mild cognitive impairment (aMCI) patients, and healthy controls (HCs) as well as potential associations with altered regional cerebral blood flow (rCBF). The recognition memory task with emotional pictures was applied to evaluate enhancement of emotional memory (EEM) and 3D pseudo-continuous arterial spin labeling MRI was performed to measure the rCBF in 74 AD patients (41 females), 74 aMCI patients (45 females), and 74 HCs (43 females). Group differences in EEM were tested by two-way analysis of covariance (ANCOVA) with repeated measures. The main effects of clinical group and sex as well as group $\times <!--\; ??\; -->$ sex interactions on rCBF were assessed by two-way ANCOVA. Correlation analyses were conducted to investigate associations between EEM and rCBF. With disease progression, EEM gradually disappeared. Among aMCI patients, females exhibited a greater index of recollection (Pr) for positive/high-arousal and negative/low-arousal pictures versus neutral pictures (P = 0.005, P = 0.003), while males exhibited a greater Pr for negative/high-arousal versus neutral pictures (P = 0.001). There were significant sex $\times <!--\; ??\; -->$ group effects on rCBF in left inferior parietal, supramarginal, superior temporal and middle temporal gyri, and rCBF of left inferior parietal gyrus was correlated with Pr for positive/high-arousal pictures among female aMCI patients (r = 0.584, q = 0.005). Males and females exhibit distinct changes in EEM associated with altered rCBF, which should be considered in future neuroimaging studies.