[en] The Ohio State University research reactor (OSURR) is undergoing improvements in its research and educational capabilities. A computer-based digital data acquisition system, including a reactor system mimic, will be installed as part of these improvements. The system will monitor the reactor system parameters available to the reactor operator either in digital parameters available to the reactor operator either in digital or analog form. The system includes two computers. All the signals are sent to computer 1, which processes the data and sends the data through a serial port to computer 2 with a video graphics array VGA monitor, which is utilized to display the mimic system of the reactor

[en] We investigate the time evolution of a coupled harmonic-oscillator chain under two boundary conditions: two ends fixed and one end fixed. The dynamics of the coupled chain and the steady variances of the coordinates are explicitly analyzed by the entire Hamiltonian using a diagonalization approach. Our result shows the desirable symmetry for the case with two ends fixed. In particular, a Langevin simulation technique is proposed to sample the harmonic chain across the entire equilibrium distribution. (authors)

[en] Computation of compressible multi-fluid flows with a general equation of state using interface tracking and moving grid approach is discussed in this paper. The AUSM+, HLLC, and Godunov methods are presented and implemented in the context of arbitrary Lagrangian-Eulerian formulation for solving the unsteady compressible Euler equations. The developed methods are fully conservative, and used to compute a variety of multi-component flow problems, where the equations of state can be drastically different and stiff. Numerical results indicate that both ALE HLLC and Godunov schemes demonstrate their simplicity and robustness for solving such multi-phase flow problems, and yet ALE AUSM+ scheme exhibits strong oscillations around material interfaces even using a first order monotone scheme and therefore is not suitable for this class of problems

[en] Dipole interaction makes average energy barrier of magnetic fine particles for thermal relaxation reduced while the corresponding blocking temperature distribution is a function of both dipolar interaction strength and particle size distribution of the system. Flatness and fast drop-off of the λ-shape behavior of the field-cooled and zero-field-cooled magnetization varies with both dipolar intereaction strength and field level applied

[en] miR-4458, a new tumor-suppressor, was reported to down-regulated in human hepatocellular carcinoma. The expression status, roles and inhibitory mechanisms of miR-4458 in other tumors still need to be clarified. The aim of this study is to investigate the effects of miR-4458 and to elucidate the potential mechanism in colon cancer cells. Using bioinformatic databases, we predicted that hexokinase2 (HK2), a rate-limiting enzyme in the glycolytic pathway, was a target of miR-4458, so the effects of miR-4458 on glycolysis and lactate production was assessed in colon cancer cells. We found that miR-4458 was down-regulated and HK2 was up-regulated in colon cancer cells. Overexpression of miR-4458 inhibited proliferation, glycolysis, and lactate production under both normoxic and hypoxic conditions. Luciferase activity assays showed that HK2 was a direct target of miR-4458. Moreover, knockdown of HK2 by specific RNAi also suppressed proliferation, glycolysis, and lactate production under both normoxic and hypoxic conditions. In conclusion, our findings suggested that miR-4458 inhibited the progression of colon cancer cells by inhibition of glycolysis and lactate production via directly targeting HK2 mRNA. - Highlights: • miR-4458 is down-regulated in colon cancer cells. • miR-4458 suppresses proliferation, glycolysis, and lactate production. • HK2 is a target of miR-4458. • HK2 knockdown inhibits proliferation, glycolysis, and lactate production.

[en] We investigate the controlled implementation of a non-local CNOT operation using a three-qubit entangled state. Firstly, we show how the non-local CNOT operation can be implemented with unit fidelity and unit probability by using a maximally entangled GHZ state as controlled quantum channel. Then, we put forward two schemes for conclusively implementing the non-local operation with unit fidelity by employing a partially entangled pure GHZ state as quantum channel. The feature of these schemes is that a third side is included, who may participate the process of quantum non-local implementation as a supervisor. Furthermore, when the quantum channel is partially entangled, the third one can rectify the state distorted by imperfect quantum channel. In addition to the GHZ class state, the W class state can also be used to implement the same non-local operation probabilistically. The probability of successful implementation using the W class state is always less than that using the GHZ class state.

[en] Objective: To investigate the rule of the aquaporin-4 (AQP-4) expression in the acute ischemic cerebral tissues, and to study the molecular biologic mechanism of diffusion-weighted imaging (DWI). Methods: Thirty-six Wistar rats were divided into 2 groups randomly, including control group (n=12) and operation group (n=24). The operation group was studied after the right middle cerebral artery was unilaterally occluded (MCAO) at an interval of 15 min, 30 min, 1 h, 3 h, 6 h, and 24 h, respectively (n=4 for each sub-group). The operation process of the control group was the same as the operation group except MCAO. All rats in both groups were examined with DWI. The relative ADC (rADC), relative density (rd), and relative area (rs) of the biggest hyperintensity signal layer on DWI were measured. After that, the animals were sacrificed and perfused with the mixture solution consisting of TTC at different time intervals. The biggest layer of the ischemic cerebral tissues stained with TTC and corresponding to that of DWI was examined with immunochemistry and in situ hybridization. The AQP-4 expression AQP-4 (ΔS and α) was measured with the Image Analyzer. Meanwhile, histologic examination was performed at each group. Results: There was no significant change of the DWI and the pathology, as well as the AQP-4 expression in the control group. In the operation group, abnormal high intensity was found in DWI of ipsilateral MCA territory at 15 min after MCAO, and rADC value decreased quickly within 1 h after MCAO, while the AQP-4 expression, the rd-DWI, and the rs-DWI increased rapidly in the stage. With the progress of the time, the rADC value further decreased at 3 h, and then began increasing slowly till 24 h. But the AQP-4 expression (ΔS and α) and the rd as well as the rs continuously increased slowly between 1 h and 6 h after MCAO, then they had an increasing peak except the rd. The AQP-4 expression, rd-DWI, and rs-DWI all showed positive linear relationship with time, presenting as 2 peaks and a plateau. The corresponding sequential pathologic changes were gradual increase of intracellular edema (<1 h) , then emergence of vasogenic and cytotoxic edema (1-6 h) , and final necrosis and liquefaction (6-24 h). Conclusion: The high expression of AQP-4 in the acute ischemic cerebral tissues played a significant role in the intracellular edema. Certainly, it was also one of the important reasons of the decrease of rADC and hyperintensity on DWI in the early stage of the cerebral ischemia

[en] Femtosecond photoionization studies in neat water at room temperature have been performed. After the electron has solvated, we have seen for the first time geminate recombination of the electron-cation pair formed upon ionization. The recombination kinetics appears to level off after roughly 60 ps with 50-60% of the electrons having undergone geminate recombination

[en] We present a scheme for implementing locally a nonlocal N-target controlled–controlled gate with unit probability of success by harnessing two (N+1)-qubit Greenberger–Horne–Zeilinger (GHZ) states as quantum channel and N qutrits as catalyser. The quantum network that implements this nonlocal (N+2)-body gate is built entirely of local single-body and two-body gates, and has only (3N+2) two-body gates. This result suggests that both the computational depth of quantum network and the quantum resources required to perform this nonlocal gate might be significantly reduced. This scheme can be generalized straightforwardly to implement a nonlocal N-target and M-control qubits gate. (paper)

[en] The long-time behavior of a system is suggested to confirm nonergodicity of non-Markovian Brownian dynamics, namely, whether the stationary probability density function (PDF) of the system characterized mainly by low moments of variables depends on the initial preparation. Thus we classify nonergodic Brownian motion into two classes: the class-I is that the PDF of a force-free particle depends on the initial velocity and the equilibration can be recovered through a bounded potential; while the PDF in the class-II depends on the initial coordinate and the equilibration can not be approached by introducing any potential. We also compare our result with the conditions of three kinds for ergodicity. (general)