[en] Highlights: • A method was developed to determine personal care products (PCPs) in fish plasma. • The MQLs of most PCPs ranged at 0.85–18.5 ng/mL (except clotrimazole at 77.5 ng/mL). • Thirteen PCPs were detected in plasma from fish collected from the Yangtze River. • Parabens and triclosan with OH group showed high ratio of conjugation up to 86%. • Five PCPs are recognized as the priority attended chemicals. -- Abstract: We used a hybrid precipitation method to simultaneously extract and analyze 24 personal care products (PCPs), including 16 biocides, 4 synthetic musks, and 4 benzotriazoles, in the plasma of fish. The method's performance was validated for plasma samples with and without β-glucuronidase/aryl-sulfatase hydrolysis. The recoveries were in the range of 70–120% for most of the PCPs, except N,N-diethyl-3-methylbenzamide (DEET), clotrimazole (CTZ), miconazole and itraconazole at spiking concentration of 20 and 5 ng/mL. The quantification limits ranged between 0.89 and 17.9 ng/mL (hydrolyzed plasma) and 0.85–18.5 ng/mL (non-hydrolyzed plasma), except CTZ at 77.5 ng/mL and 76.3 ng/mL. Totally, 13 PCPs were detected in plasma samples of fish collected from the Yangtze River, with a maximum concentration of 58.4 ng/mL (galaxolide). Compounds with the phenol hydroxyl groups of parabens or triclosan in hydrolyzed plasma showed higher concentrations than those in unhydrolyzed plasma with the ratio of conjugation (glucuronides + sulfates) forms up to 86%. The median values for the logarithm of bioaccumulation factors were between 1.39 and 4.15, which were 2–3 orders of magnitude higher than the theoretical logarithm of bioconcentration factors. Using the fish plasma model, the effect ratios (effect concentration/measured plasma concentration ratios) of tonalide, galaxolide, benzotriazole, triclosan, and DEET reached 0.35, 4.15, 3.78, 7.52, and 9.24, respectively. These are recognized as priority chemicals for further risk assessment.

[en] Highlights: • Antibiotics in black-odor sediments across China were investigated systematically for the first time. • Totally 36 out of 44 antibiotics were detected in the sediment samples. • Oxytetracycline, ofloxacin, norfloxacin and tetracycline were the dominant antibiotics. • 12 antibiotic concentrations were positively related to total organic carbon. • Significant correlations were found between some antibiotics from same or different classes. Antibiotic levels in black-odor water could reflect the usage amount of antibiotics in population. On the other hand, these antibiotics are the source of antibiotics in the environmental water. Currently, researches on antibiotics in black-odor sediments are still lacking. In this study, 174 black and odor sediment samples from 74 cities in 28 provinces in China were collected for analysis. Among 44 targeted antibiotics, 13 antibiotics were detected in more than 30% of sediment samples. Fluoroquinolones and tetracyclines were the predominant antibiotics in these field samples, with average concentrations of up to 2074 and 1902 ng/g dry weight (dw), respectively, followed by macrolides (87.9 ng/g dw), lincosamides (8.06 ng/g dw) and sulfonamides (8.38 ng/g dw). High antibiotic contamination levels were almost always detected in black-odor sludges from economically less developed small cities; however, the difference in antibiotic concentrations between well-developed and small cities in China was not statistically significant. In addition, among the seven regions within China, no significant difference in concentrations was observed for the most antibiotics. Variances in antibiotic composition patterns in the 28 provinces of China may be due to differences in bacterial resistance, prescription habits, efficacy, and sediment carbon concentrations among various regions. There were significant positive correlations among some antibiotics in the same or different classes.