[en] More than 35 million high-energy muons collected with the MACRO detector at the underground Gran Sasso Laboratory have been used to search for flux variations of different nature. Two kinds of studies were carried out: a search for the occurrence of clusters of events and a search for periodic variations. Different analysis methods, including the Scan Statistics test and the Lomb-Scargle spectral analysis have been applied to the data. The seasonal modulation was confirmed. The signals at the positions of solar diurnal and sidereal modulations are confirmed, even if with smaller significance. No other deviations from the expected distributions were found